Ayatollahi P, Nafissi S, Eshraghian M R, Kaviani H, Tarazi A
Department of Neurology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Mult Scler. 2007 Mar;13(2):275-7. doi: 10.1177/1352458506070960. Epub 2007 Jan 29.
Multiple sclerosis (MS) can influence all aspects of a patient's health. This study determines the main factors affecting quality of life (QoL) in Iranian MS patients. QoL (Multiple Sclerosis Impact Scale; MSIS-29), disability (Expanded Disability Status Scale; EDSS) and depression (Beck Depression Inventory; BDI) were assessed in 106 MS patients. EDSS, clinical course and MS duration significantly correlated with physical MSIS-29. Depression highly correlated with both physical and psychological MSIS-29. Regression analyses showed that depression and EDSS predicted physical health. Psychological health was predicted by depression. These findings highlight that depression and physical disability strongly influence QoL in Iranian MS patients.
多发性硬化症（MS）会影响患者健康的各个方面。本研究确定了影响伊朗MS患者生活质量（QoL）的主要因素。对106例MS患者评估了生活质量（多发性硬化症影响量表；MSIS-29）、残疾程度（扩展残疾状态量表；EDSS）和抑郁情况（贝克抑郁量表；BDI）。EDSS、临床病程和MS持续时间与MSIS-29身体维度显著相关。抑郁与MSIS-29身体和心理维度均高度相关。回归分析表明，抑郁和EDSS可预测身体健康状况。抑郁可预测心理健康状况。这些发现突出表明，抑郁和身体残疾对伊朗MS患者的生活质量有强烈影响。
