[严重烧伤患者早期胆固醇水平及红细胞膜钠钾ATP酶活性的变化]
[The change of cholesterol level and Na+ -K+ -ATPase activity of erythrocyte membrane in early stage of severe burn patients].
作者信息
Lv Da-lun, Cui Fan, Li Xiao-ning
机构信息
Department of Burns, 2.Laboratoy, Affiliated Hospital of Wannan Medical College, Wuhu 241001, China.
出版信息
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2002 Nov;18(4):391-3.
AIM
To study the relationship between erythrocyte filtration index (EFI) and cholesterol and Na+ -K+ -ATPase activity of erythrocyte membrane in early stage of severe burns.
METHODS
The EFI was measured by means of percolation, the erythrocyte membrane cholesterol level was measured by means of chemically modified electrode, and the membrane Na+ -K+ -ATPase activity by means of detection of Pi.
RESULTS
In early stage of severe burns, the cholesterol level and Na+ -K -ATPase activity of erythrocyte membrane were always higher than those of control group (P < 0.01), but the EFI was lower than that of control group (P < 0.01). The cholesterol level and Na+ -K+ -ATPase activity of the erythrocyte membrane were negative correlation with EFI (r cho= -0.871, r ATPase = -0.801, P < 0.01) nospectively.
CONCLUSION
The cholesterol level and Na+ -K+ -ATPase activity of erythrocyte membrane play a key role in the change of EFI.
目的
研究严重烧伤早期红细胞滤过指数（EFI）与胆固醇及红细胞膜钠钾ATP酶活性之间的关系。
方法
采用滤过法测定EFI，用化学修饰电极法测定红细胞膜胆固醇水平，通过检测无机磷测定膜钠钾ATP酶活性。
结果
严重烧伤早期，红细胞膜胆固醇水平和钠钾ATP酶活性均高于对照组（P<0.01），但EFI低于对照组（P<0.01）。红细胞膜胆固醇水平和钠钾ATP酶活性与EFI呈负相关（r胆固醇=-0.871，rATP酶=-0.801，P<0.01）。
结论
红细胞膜胆固醇水平和钠钾ATP酶活性在EFI变化中起关键作用。
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