Protzner A B, Valiante T A, Kovacevic N, McCormick C, McAndrews M P
Krembil Neuroscience Centre, Toronto Western Hospital and Research Institute, University Health Network, Toronto, ON, Canada.
Arch Ital Biol. 2010 Sep;148(3):289-97.
Patients with mesial temporal lobe epilepsy (mTLE) show structural and functional abnormalities in hippocampus and surrounding mesial temporal structures. Brain signal complexity appears to be a marker of functional integrity or capacity. We examined complexity in 8 patients with intracranial hippocampal electrodes during performance of memory tasks (scene encoding and recognition) known to be sensitive to mesial temporal integrity. Our patients were shown to have right mesial temporal seizure onsets, permitting us to evaluate both epileptogenic (right) and healthy (left) hippocampi. Using multiscale entropy (MSE) as a measure of complexity, we found that iEEG from the epileptogenic hippocampus showed less complexity than iEEG from the healthy hippocampus. This difference was reliable for encoding but not for recognition. Our results indicate that both functional integrity and cognitive demands influence hippocampal signal complexity.
内侧颞叶癫痫（mTLE）患者的海马体及周围内侧颞叶结构存在结构和功能异常。脑信号复杂性似乎是功能完整性或能力的一个标志。我们在8名植入颅内海马电极的患者执行已知对内侧颞叶完整性敏感的记忆任务（场景编码和识别）期间，检测了信号复杂性。我们的患者表现为右侧内侧颞叶癫痫发作起始，这使我们能够评估致痫（右侧）和健康（左侧）海马体。使用多尺度熵（MSE）作为复杂性的度量指标，我们发现来自致痫海马体的颅内脑电图（iEEG）比来自健康海马体的iEEG复杂性更低。这种差异在编码时是可靠的，但在识别时不可靠。我们的结果表明，功能完整性和认知需求都会影响海马体信号复杂性。
