Akhoundi Mohammad S A, Dehpour Ahmad Reza, Rashidpour Mahsa, Alaeddini Mojgan, Kharazifard Mohammad Javad, Noroozi Hassan
Department of Orthodontics, Tehran University of Medical Sciences, Tehran, Iran.
Aust Orthod J. 2010 Nov;26(2):113-8.
To investigate the effect of morphine as an exogenous opioid on orthodontic tooth movement. Naltrexone will be used as an opioid antagonist to confirm the results.
Forty rats were randomly divided into four equal groups. The first group received no injection; the second group received daily injections of morphine; the third group received daily naltrexone-morphine injections and the fourth group daily injections of naltrexone-normal saline. The left first maxillary molar in each rat was tipped mesially with a NiTi closed coil spring. The rats were sacrificed after 14 days and the maxillae fixed, sectioned serially and examined histologically.
The greatest amount of tooth movement occurred in the Control group and the least amount of tooth movement in the Morphine group. Tooth movement in the Morphine group was significantly different from the other three groups (p < 0.05). The differences in tooth movement in the Control, Morphine-naltrexone and Naltrexonesaline groups were not statistically significant (p > 0.05). No statistically significant histological differences were found.
Morphine reduced orthodontic tooth movement in rats. This effect was reversed by the opioid antagonist, naltrexone, which had no effect on tooth movement.
研究外源性阿片类药物吗啡对正畸牙齿移动的影响。将使用纳曲酮作为阿片类拮抗剂来证实结果。
40只大鼠随机分为四组，每组数量相等。第一组不注射；第二组每日注射吗啡；第三组每日注射纳曲酮 - 吗啡；第四组每日注射纳曲酮 - 生理盐水。用镍钛闭合曲簧将每只大鼠的左侧上颌第一磨牙向近中倾斜。14天后处死大鼠，固定上颌骨，连续切片并进行组织学检查。
对照组牙齿移动量最大，吗啡组牙齿移动量最小。吗啡组的牙齿移动与其他三组有显著差异（p < 0.05）。对照组、吗啡 - 纳曲酮组和纳曲酮 - 生理盐水组的牙齿移动差异无统计学意义（p > 0.05）。未发现有统计学意义的组织学差异。
吗啡减少大鼠正畸牙齿移动。阿片类拮抗剂纳曲酮可逆转这种作用，且纳曲酮对牙齿移动无影响。
