Olsson S E, Odlind V, Johansson E
Department of Obstetrics and Gynecology, University of Uppsala, Sweden.
Contraception. 1990 Jul;42(1):1-11. doi: 10.1016/0010-7824(90)90087-c.
Eight healthy women using one Silastic implant of 30 mm length filled with 3-keto desogestrel, the active metabolite of desogestrel, were studied for 36-664 days. The release rate of 3-keto desogestrel was quite constant and around 30 micrograms/day. No ovulations occurred. One woman was amenorrheic, while the others had different bleeding patterns, often with periods of spotting. No other side effects were recorded. The mean plasma levels of 3-keto desogestrel were 0.9 nmol/l after 1 month and 0.5 nmol/l after 12 months. 3-Keto desogestrel was less effective than testosterone, estradiol or levonorgestrel in displacing 3H-dihydrotestosterone from SHBG. It is concluded that contraception with 3-keto desogestrel delivered through an implant is a promising method for further investigation. With a single implant we found a duration of at least one year.
八名健康女性使用了一根长度为30毫米、填充有地索高诺酮的活性代谢物3-酮地索高诺酮的硅橡胶植入物，研究时间为36至664天。3-酮地索高诺酮的释放速率相当恒定，约为30微克/天。未发生排卵现象。一名女性闭经，其他女性则有不同的出血模式，经常出现点滴出血。未记录到其他副作用。3-酮地索高诺酮的平均血浆水平在1个月后为0.9纳摩尔/升，12个月后为0.5纳摩尔/升。在从性激素结合球蛋白（SHBG）置换3H-二氢睾酮方面，3-酮地索高诺酮的效果不如睾酮、雌二醇或左炔诺孕酮。结论是，通过植入物递送3-酮地索高诺酮进行避孕是一种有前景的可供进一步研究的方法。使用单个植入物，我们发现其有效期至少为一年。
