Gastroenterology Department, Instituto Portugus de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal.
BioDrugs. 2010 Dec 14;24 Suppl 1:15-7. doi: 10.2165/11586250-000000000-00000.
Systemic AA amyloidosis is a serious complication of many chronic inflammatory disorders. Its association with Crohn's disease implies that the inflammatory burden is high enough for amyloid fibrils to form deposits in tissues. A case is presented in which this complication occurred while the patient was clinically well, with biological and endoscopic markers showing an inactive or mildly active disease under anti-tumor necrosis factor alpha therapy.
系统性 AA 淀粉样变性是许多慢性炎症性疾病的严重并发症。它与克罗恩病有关，这意味着炎症负担高到足以使淀粉样纤维在组织中形成沉积物。本文报告了一例在患者临床状况良好时发生这种并发症的病例，生物标志物和内镜检查显示在抗肿瘤坏死因子 α 治疗下疾病处于不活动或轻度活动状态。
