Gastroenterology Department, Instituto Portugus de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal.
BioDrugs. 2010 Dec 14;24 Suppl 1:25-7. doi: 10.2165/11586210-000000000-00000.
Infliximab and adalimumab are anti-tumor necrosis factor (TNF) alpha agents used for treating Crohn's disease. Autoimmune hepatitis (AIH) is a rare complication of treatment with these drugs. We report on a case of AIH in a patient with Crohn's disease treated with infliximab who fully recovered after drug withdrawal. More interestingly, because there were no other treatment options, the patient was then treated with adalimumab without recurrence of the liver disease and with control of the intestinal disease.
英夫利昔单抗和阿达木单抗是用于治疗克罗恩病的抗肿瘤坏死因子 (TNF)α 药物。自身免疫性肝炎 (AIH) 是这些药物治疗的罕见并发症。我们报告了一例使用英夫利昔单抗治疗的克罗恩病患者发生 AIH 的病例，该患者停药后完全康复。更有趣的是，由于没有其他治疗选择，该患者随后使用阿达木单抗治疗，肝脏疾病未再复发，肠道疾病得到控制。
