Barroso Mário, Gallardo Eugenia, Vieira Duarte Nuno, López-Rivadulla Manuel, Queiroz João António
Instituto Nacional de Medicina Legal, Delegação do Sul, Rua Manuel Bento de Sousa, 3, 1150-219 Lisboa, Portugal.
Bioanalysis. 2011 Jan;3(1):67-79. doi: 10.4155/bio.10.171.
Hair has been used for years in the assessment and documentation of human exposure to drugs, as it presents characteristics that make it extremely valuable for this purpose, namely the fact that sample collection is performed in a noninvasive manner, under close supervision, the possibility of collecting a specimen reflecting a similar timeline in the case of claims or suspicion of a leak in the chain of custody, and the increased window of detection for the drugs. For these reasons, testing for drugs in hair provides unique and useful information in several fields of toxicology, from which the most prominent is the possibility of studying individual drug use histories by means of segmental analysis. This paper will review the unique role of hair as a complementary sample in documenting human exposure to drugs in the fields of clinical and forensic toxicology and workplace drug testing.
多年来，毛发一直被用于评估和记录人体对药物的暴露情况，因为它具有一些特性，使其在此目的上极具价值，即样本采集以非侵入性方式进行，且在密切监督下进行；在保管链出现索赔或怀疑有泄露的情况下，有可能采集到反映相似时间线的样本；以及药物检测窗口期延长。基于这些原因，毛发药物检测在毒理学的多个领域提供了独特且有用的信息，其中最突出的是通过分段分析研究个体用药史的可能性。本文将综述毛发作为补充样本在临床和法医毒理学以及工作场所药物检测领域记录人体药物暴露方面的独特作用。
