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液相色谱-低分辨和高分辨质谱联用在临床和法医毒理学中用于药物的筛查、鉴定和定量的研究进展。

Perspectives of liquid chromatography coupled to low- and high-resolution mass spectrometry for screening, identification, and quantification of drugs in clinical and forensic toxicology.

机构信息

Department of Experimental and Clinical Toxicology, Saarland University, Homburg, Germany.

出版信息

Ther Drug Monit. 2010 Jun;32(3):324-7. doi: 10.1097/FTD.0b013e3181dca295.

DOI:10.1097/FTD.0b013e3181dca295
PMID:20418802
Abstract

This article reviews papers on the use of liquid chromatography coupled to low- and high-resolution mass spectrometry in clinical and forensic toxicology. They cover procedures for target and for more comprehensive screening for drugs (of abuse), identification of drug metabolites, and multianalyte procedures for quantification of drugs and/or their metabolites in body samples. Besides a critical overview, perspectives are discussed.

摘要

本文综述了液相色谱-低分辨和高分辨质谱联用在临床和法医毒理学中的应用。涵盖了针对目标物和更全面的药物（滥用）筛选、药物代谢物鉴定以及用于定量检测生物样品中药物和/或其代谢物的多分析物程序。除了批判性的回顾，还讨论了展望。

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