Hunt J V, Wolff S P
Department of Clinical Pharmacology, University College London, UK.
FEBS Lett. 1990 Aug 20;269(1):258-60. doi: 10.1016/0014-5793(90)81168-n.
Reactions between glucose and protein are held to be responsible for the protein 'browning' reactions which occur in diabetes mellitus. In vitro, however, the formation of such novel protein fluorophores is dependent upon the metal-catalysed oxidation of the monosaccharide (glucose 'autoxidation'). Since other small oxidisable molecules are capable of 'browning' proteins via similar metal-catalysed oxidative mechanisms we suggest that protein modification in diabetes may not be restricted to reactions with monosaccharides but may also include other small autoxidisable molecules.
葡萄糖与蛋白质之间的反应被认为是糖尿病中发生的蛋白质“褐变”反应的原因。然而，在体外，此类新型蛋白质荧光团的形成取决于单糖的金属催化氧化（葡萄糖“自氧化”）。由于其他可氧化小分子能够通过类似的金属催化氧化机制使蛋白质“褐变”，我们认为糖尿病中的蛋白质修饰可能不仅限于与单糖的反应，还可能包括其他可自氧化的小分子。
