van Boekel M A
Department of Biochemistry, University of Nijmegen, The Netherlands.
Mol Biol Rep. 1991 May;15(2):57-64. doi: 10.1007/BF00364840.
One of the hypotheses trying to explain the process of aging is the idea of glycation of proteins. This reaction, also called the Maillard or browning reaction, may explain age-related symptoms such as cataract, atherosclerosis and modification of collagen-containing tissues. Diabetics, which possess elevated blood sugar levels, show signs of accelerated aging exposing similar complications. The Maillard reaction, which occurs on a large scale in vivo, may play a key role in the initiation of these symptoms.
试图解释衰老过程的假说之一是蛋白质糖基化的观点。这种反应，也称为美拉德反应或褐变反应，可能解释与年龄相关的症状，如白内障、动脉粥样硬化以及含胶原蛋白组织的改变。糖尿病患者血糖水平升高，表现出加速衰老的迹象，出现类似的并发症。在体内大规模发生的美拉德反应可能在引发这些症状中起关键作用。
