Immunology, Inserm 940-IUH-Hopital Saint-Louis, Paris, France.
Vox Sang. 2011 Jan;100(1):163-6. doi: 10.1111/j.1423-0410.2010.01438.x.
Displaying the highest level of diversity of any functional genetic complex with medical impact, the HLA system represents a landmark and a model for the development of predictive and preventive medicine. The massive amount of data which will soon be obtained through new high through put technologies for individual genomes and transcriptomes challenges the HLA and medicine paradigm. Systems biology approach and integrative methodologies will undoubtedly be needed to unravel the ever growing number of HLA and diseases associations and the role of immunogenetics in transplantation and other allogeneic cell therapies. Also HLA, immunogenetics and pharmacogenetics are merging to bring to the individual patient tailored and personalized treatment. Providing insights into the complexities of predictive, preventive participatory and personalized medicine, the role of the HLA system will be consolidated at the forefront of the newer medicine.
HLA 系统是具有医学影响的功能基因复合体中多样性最高的，它代表了预测性和预防性医学发展的一个里程碑和模型。通过新的高通量技术获取个体基因组和转录组的海量数据，这给 HLA 和医学领域带来了挑战。为了揭示 HLA 与疾病之间越来越多的关联，以及免疫遗传学在移植和其他同种异体细胞治疗中的作用，系统生物学方法和综合方法无疑是必要的。此外，HLA、免疫遗传学和药物遗传学正在融合，为个体患者带来量身定制的个性化治疗。HLA 系统在预测性、预防性、参与性和个性化医学的复杂性方面提供了深入的见解，它将在新医学的前沿得到巩固。
