National TCM Key Lab of Serum Pharmacochemistry, Heilongjiang University of Chinese Medicine, and Key Pharmacometabolomics Platform of Chinese Medicines, Heping Road 24, Harbin 150040, China.
Complement Ther Med. 2012 Feb-Apr;20(1-2):93-9. doi: 10.1016/j.ctim.2011.10.007. Epub 2011 Nov 30.
Deconstruction of molecular pathways and advances in enabling technology platforms have opened new horizons for disease management, exploring therapeutic solutions to each individual patient beyond the one-size fits all practice. Application of personalized medicine paradigms aims to achieve the right diagnosis and right treatment for the right patient at the right time at the right cost. With the potential to transform medical practice across global communities, personalized medicine is emerging as the flagship of modern medicine. In recent years, the health care paradigm has shifted from a focus on diseases to a major hot of personalized traditional Chinese medicine (TCM) with holistic approach. TCM focuses on health maintenance, emphasizes on enhancing the body's resistance to diseases and especially showes great advantages in early intervention, personalized and combination therapies, etc. Systems biology, a new science of the 21st century, becomes practically available and resembles TCM in many aspects such as study method and design, and is current key component technologies that serves as the major driving force for translation of the personalized medicine revolution of TCM principles into practice, will advance personalized therapy principles into healthcare management tools for individuals and populations. Such system approach concepts are transforming principles of TCM to modern therapeutic approaches, enable a predictive and preventive medicine and will lead to personalized medicine. To realise the full potential of personalized TCM, we describe the current status of principles and practice of TCM integrated with systems biology platform. Some characteristic examples are presented to highlight the application of this platform to personalized TCM research and development as well as some of the necessary milestones for moving TCM into mainstream health care.
分子途径的解构和使能技术平台的进步为疾病管理开辟了新的视野，超越了一刀切的实践，为每个个体患者探索治疗解决方案。个性化医学范式的应用旨在以合适的成本在合适的时间为合适的患者提供正确的诊断和正确的治疗。个性化医学有可能改变全球社区的医疗实践，正在成为现代医学的旗舰。近年来，医疗保健模式已从关注疾病转变为以整体方法为重点的个性化传统中医（TCM）的主要热点。TCM 专注于健康维护，强调增强身体对疾病的抵抗力，特别是在早期干预、个性化和联合治疗等方面具有很大优势。系统生物学是 21 世纪的一门新兴科学，在研究方法和设计等方面与 TCM 非常相似，是目前关键的组成技术，是将 TCM 个体化医学原理转化为实践的主要驱动力，将个性化治疗原理推进到个人和人群的医疗保健管理工具中。这种系统方法的概念正在将 TCM 的原则转化为现代治疗方法，实现预测性和预防性医学，并将导致个性化医学。为了充分发挥个性化 TCM 的潜力，我们描述了与系统生物学平台相结合的 TCM 原则和实践的现状。介绍了一些典型的例子，以强调该平台在个性化 TCM 研究与开发中的应用，以及将 TCM 推向主流医疗保健所需的一些必要里程碑。
