Institute of Zoonoses, College of Animal Sciences and Veterinary Medicine, Jilin University, Changchun, China.
FEMS Microbiol Lett. 2011 Feb;315(2):129-33. doi: 10.1111/j.1574-6968.2010.02183.x. Epub 2010 Dec 22.
In this study, the antibacterial activity of farrerol against Staphylococcus aureus was determined. The minimum inhibitory concentrations capable of inhibiting 35 S. aureus strains ranged from 4 to 16 μg mL(-1) . A haemolysis assay, Western blot and real-time reverse transcriptase-PCR assay were performed to identify the influence of subinhibitory concentrations of farrerol on the secretion of α-toxin by S. aureus. The results show that farrerol significantly decreased, in a dose-dependent manner, the production of α-toxin by both methicillin-sensitive S. aureus and methicillin-resistant S. aureus.
在这项研究中，测定了法呢醇对金黄色葡萄球菌的抗菌活性。能够抑制 35 株金黄色葡萄球菌的最小抑菌浓度范围为 4 至 16 μg/mL。通过溶血试验、Western blot 和实时逆转录聚合酶链反应试验，鉴定了亚抑菌浓度的法呢醇对金黄色葡萄球菌α-毒素分泌的影响。结果表明，法呢醇显著降低了耐甲氧西林金黄色葡萄球菌和耐甲氧西林金黄色葡萄球菌α-毒素的产生，呈剂量依赖性。
