Iwama M, Tojima T, Iitoi Y, Takahashi N, Kanke Y
Dept. of Nutrition, Tokyo University of Agriculture, Japan.
Int J Vitam Nutr Res. 1990;60(1):100-3.
Capsaicin (CAP; 50 mg/kg body wt., p.o.) and/or ethanol (EtOH; 10% (v/v) in the drinking water) were given for a period of 30 days to male rats, and changes in hepatic drug-metabolizing enzymes were investigated. The EtOH alone tended to increase the microsomal parameters such as cytochrome P-450 content and enzyme activities of aniline hydroxylase, aminopyrine demethylase and UDP-glucuronyl transferase, while it did not affect the cytosolic enzyme activities of sulfotransferase and glutathione S-transferase. The administration of CAP without EtOH tended to decrease all of the parameters studied. In contrast, the ingestion of CAP with EtOH tended to increase even the elevated microsomal enzyme activities by EtOH alone. These data suggest that chronic alcohol ingestion could modify the potential for detoxification of xenobiotics in persons who regularly consume a large amount of hot peppers.
给雄性大鼠口服辣椒素（CAP；50毫克/千克体重）和/或乙醇（EtOH；饮用水中10%（v/v）），持续30天，然后研究肝脏药物代谢酶的变化。单独给予乙醇往往会增加微粒体参数，如细胞色素P - 450含量以及苯胺羟化酶、氨基比林脱甲基酶和UDP - 葡萄糖醛酸转移酶的酶活性，而对胞质硫酸转移酶和谷胱甘肽S - 转移酶的酶活性没有影响。单独给予辣椒素往往会使所研究的所有参数降低。相反，同时摄入辣椒素和乙醇甚至会使仅由乙醇引起升高的微粒体酶活性进一步增加。这些数据表明，长期饮酒可能会改变经常大量食用辣椒的人群对外源化学物质的解毒能力。
