Iwasaki M, Iwama M, Miyata N, Iitoi Y, Kanke Y
Dept. of Nutrition, Tokyo University of Agriculture, Japan.
Int J Vitam Nutr Res. 1994;64(2):109-12.
The effects of a vitamin E (VE) deficient diet given for 120 days on total cytochrome P450 (P450) contents and UDP-glucuronyl transferase (UDPGT) and sulfotransferase (ST) activities were investigated in rat liver of both sexes. The VE deficient regimen lowered the serum VE levels, increasing the hepatic malondialdehyde concentration regardless of animal sex, which shows an elevation of the tissue peroxi-disability. Hepatic total P450 contents were significantly decreased in male rats given the VE deficient diet, whereas the effects on female rats were less obvious. Concerning phase II enzymes, VE deficiency had no effect on the activities of UDPGT and ST in rats of both sexes. The data suggest that overall capacity of detoxification of xenobiotics may be impaired by VE deficiency to a much greater extent in male than in female rat liver.
研究了在雌雄大鼠肝脏中，给予120天维生素E（VE）缺乏饮食对总细胞色素P450（P450）含量、UDP-葡萄糖醛酸基转移酶（UDPGT）和磺基转移酶（ST）活性的影响。无论动物性别如何，VE缺乏方案均降低了血清VE水平，增加了肝脏丙二醛浓度，这表明组织过氧化能力增强。给予VE缺乏饮食的雄性大鼠肝脏总P450含量显著降低，而对雌性大鼠的影响则不太明显。关于Ⅱ相酶，VE缺乏对雌雄大鼠的UDPGT和ST活性均无影响。数据表明，VE缺乏对雄性大鼠肝脏中外源化学物解毒总体能力的损害程度可能远大于雌性大鼠。
