Department of Ophthalmology, Vietnam Military Medical University, Hanoi, Vietnam.
Clin Exp Ophthalmol. 2011 Jul;39(5):386-92. doi: 10.1111/j.1442-9071.2010.02479.x. Epub 2011 Mar 16.
To describe the outcome of surgery using amniotic membrane transplantation for Mooren's ulcer.
A prospective interventional case series from the Vietnam National Institute of Ophthalmology.
Eighteen eyes of 14 patients with Mooren's ulcer. Seven eyes had recurrent episodes of ulceration, and 11 were not responsive to medical therapy or conjunctival resection.
All eyes were treated with amniotic membrane grafts for Mooren's ulcer (10 eyes with multilayer grafts; 8 with a single layer graft). Five eyes with a 360° peripheral ulcer were treated with an overlay amniotic membrane graft, and 13 eyes were treated with a freehand graft tailored to fit the localized defect.
Time to epithelial healing. Visual acuity outcome.
Sixteen of 18 eyes were treated by a single surgery with amniotic membrane with rapid healing of the epithelial defect (mean time to complete epithelialization 12.4 days). Two eyes required a second amniotic membrane graft: one eye required regrafting following a subgraft haemorrhage and another eye required regrafting for a persistent epithelial defect. Vision was stabilized in all eyes with 10 of 18 eyes obtaining vision of 6/12 or better.
Amniotic membrane transplantation may be a useful treatment for selected patients with Mooren's ulcer especially where systemic immunosuppressive drugs are unavailable.
描述使用羊膜移植治疗蚕蚀性角膜溃疡的手术结果。
越南国家眼科研究所的前瞻性干预性病例系列研究。
14 名蚕蚀性角膜溃疡患者的 18 只眼。7 只眼有溃疡复发，11 只眼对药物或结膜切除术无反应。
所有眼均行羊膜移植治疗蚕蚀性角膜溃疡（10 只眼行多层移植；8 只眼行单层移植）。5 只 360°周边溃疡眼行覆盖式羊膜移植，13 只眼行游离手剪羊膜移植，以贴合局部病灶。
上皮愈合时间。视力结果。
18 只眼中的 16 只用羊膜进行了一次手术治疗，上皮缺损迅速愈合（上皮完全愈合的平均时间为 12.4 天）。2 只眼需要再次行羊膜移植：1 只眼因下植片出血需再次移植，另 1 只眼因持续上皮缺损需再次移植。所有眼的视力均稳定，18 只眼中有 10 只眼视力达到 6/12 或更好。
羊膜移植可能是治疗蚕蚀性角膜溃疡的一种有效方法，特别是在无法使用全身免疫抑制剂的情况下。
