Ou Shangkun, Zhang Yujie, Lin Yuan, Fang Xie, Xie Zhiwen, Shi Ke, Cai Minqing, Su Shengqi, Wu Huping
Xiamen Eye Center and Eye Institute of Xiamen University, School of Medicine, Xiamen, China.
Xiamen Clinical Research Center for Eye Diseases, Xiamen, Fujian, China.
Heliyon. 2024 Oct 23;10(21):e39623. doi: 10.1016/j.heliyon.2024.e39623. eCollection 2024 Nov 15.
The purpose of this study was to investigate the clinical characteristics of patients with corneal Mooren's ulcers (MU) and explore potential risk factors for recurrence after keratoplasty.
The study retrospectively analyzed 87 patients (101 eyes) diagnosed with MU. Factors associated with recurrence after keratoplasty were identified using correlation analysis, and a clinical scoring system was developed based on the magnitude of the univariate and multivariate logistic regression analysis.
The average age of onset for the 87 patients was 55.2 years old, and the male-to-female ratio was 1:0.74. Of the 101 eyes diagnosed with MU, 73 cases (83.9 %) were Unilateral. Eleven eyes (10.9 %) had a history of ocular surgery, and five (5.0 %) had a history of ocular trauma. The perforation rate was 18.8 %, and the recurrence rate after keratoplasty was 37.3 %. Ulcer depth (P < 0.05, R = -0.252), corneal perforation status (P < 0.05, R = 0.238), and history of ocular surgery or trauma (P < 0.05, R = -0.238) were associated with recurrence. Based on these findings, a clinical scoring system was constructed to evaluate the recurrence of MU.
MU mostly occurs in elderly men, often with monocular onset. The recurrence rate after keratoplasty is high at 37.3 %. Deep ulcer infiltration, corneal perforation, and a history of ocular surgery or trauma are associated with recurrence after keratoplasty. A scoring system has been established based on these clinical characteristics and can be used to predict the risk of recurrence after keratoplasty.
本研究旨在调查角膜蚕蚀性溃疡（MU）患者的临床特征，并探讨角膜移植术后复发的潜在危险因素。
本研究回顾性分析了87例（101只眼）诊断为MU的患者。采用相关性分析确定与角膜移植术后复发相关的因素，并基于单因素和多因素逻辑回归分析的结果建立了临床评分系统。
87例患者的平均发病年龄为55.2岁，男女比例为1:0.74。在101只诊断为MU的眼中，73例（83.9%）为单眼发病。11只眼（10.9%）有眼部手术史，5只眼（5.0%）有眼外伤史。穿孔率为18.8%，角膜移植术后复发率为37.3%。溃疡深度（P<0.05，R=-0.252）、角膜穿孔状态（P<0.05，R=0.238）以及眼部手术或外伤史（P<0.05，R=-0.238）与复发相关。基于这些发现，构建了一个临床评分系统来评估MU的复发情况。
MU多见于老年男性，常单眼发病。角膜移植术后复发率较高，为37.3%。溃疡浸润深、角膜穿孔以及眼部手术或外伤史与角膜移植术后复发相关。已基于这些临床特征建立了一个评分系统，可用于预测角膜移植术后的复发风险。
