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正常眼压性青光眼和原发性开角型青光眼的视盘出血的期间患病率和发病率。

Period prevalence and incidence of optic disc haemorrhage in normal tension glaucoma and primary open-angle glaucoma.

机构信息

Department of Ophthalmology, Haeundae Paik Hospital, Busan, Korea.

出版信息

Clin Exp Ophthalmol. 2011 Aug;39(6):513-9. doi: 10.1111/j.1442-9071.2010.02482.x. Epub 2011 Feb 23.

DOI:10.1111/j.1442-9071.2010.02482.x
PMID:21176041
Abstract

BACKGROUND

To investigate and compare the period prevalences and incidences of optic disc haemorrhages in normal tension glaucoma and primary open-angle glaucoma.

DESIGN

Hospital-based retrospective study.

PARTICIPANTS

Four hundred and four patients with normal tension glaucoma and 210 patients with primary open-angle glaucoma that underwent consecutive disc examinations at least quarterly for at least 1 year and stereoscopic optic disc photographs at intervals of 6 to 12 months between 1992 and 2007.

METHODS

The period prevalence of disc haemorrhages, gender predominance among patients with disc haemorrhage, and cumulative incidence of normal tension glaucoma and primary open-angle glaucoma were compared.

MAIN OUTCOME MEASURES

Period prevalence, cumulative incidence, and gender predominance of DHs in patients with NTG and POAG.

RESULTS

Three hundred and eighty-seven patients (387 eyes) of normal tension glaucoma patients and 205 patients (205 eyes) of primary open-angle glaucoma patients were finally enrolled in the study. The period prevalence and incidence rates of the stereoscopic optic disc photograph-confirmed glaucomatous disc haemorrhages were 33.3% (129/387), 0.46 ± 0.18 times/year in the normal tension glaucoma group, and 17.6% (36/205), 0.34 ± 0.23 times/year in the primary open-angle glaucoma group, respectively. The absolute values and ratios of primary open-angle glaucoma and normal tension glaucoma in period prevalences and incidence rates in the present study were higher than in previous studies. No significant difference in gender ratios was found between patients that did or did not develop disc haemorrhage for both types of open-angle glaucoma (P > 0.05, respectively).

CONCLUSIONS

The primary open-angle glaucoma group had higher period prevalences and incidence rates of disc haemorrhage than those reported previously. Disc haemorrhages were found to develop independent of gender.

摘要

背景

调查并比较正常眼压性青光眼和原发性开角型青光眼的视盘出血的现患率和发生率。

设计

基于医院的回顾性研究。

参与者

1992 年至 2007 年间,连续接受至少每季度一次的视盘检查且至少 1 年进行立体视盘照相检查、间隔 6 至 12 个月的 404 例正常眼压性青光眼患者和 210 例原发性开角型青光眼患者。

方法

比较视盘出血的现患率、视盘出血患者的性别优势以及正常眼压性青光眼和原发性开角型青光眼的累积发病率。

主要观察指标

正常眼压性青光眼和原发性开角型青光眼患者中 DH 的现患率、累积发病率和性别优势。

结果

最终纳入 387 例正常眼压性青光眼患者(387 只眼)和 205 例原发性开角型青光眼患者(205 只眼)。立体视盘照相证实的青光眼性视盘出血的现患率和发生率分别为正常眼压性青光眼组 33.3%(129/387),0.46±0.18 次/年;原发性开角型青光眼组 17.6%(36/205),0.34±0.23 次/年。本研究现患率和发生率的原发性开角型青光眼和正常眼压性青光眼的绝对值和比值均高于以往研究。两种类型的开角型青光眼患者中,发生或未发生视盘出血的患者在性别比例方面无显著差异(分别为 P>0.05)。

结论

原发性开角型青光眼组的视盘出血现患率和发生率高于以往报道。视盘出血的发生与性别无关。

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