Department of Orthopedic Surgery, Kobe University Graduate School of Medicine, Chuo-ku, Kobe, Japan.
Cell Transplant. 2011;20(9):1491-6. doi: 10.3727/096368910X550189. Epub 2010 Dec 22.
Although implantation of crude bone marrow cells has been applied in a small number of patients for fracture healing, transplantation of peripheral blood CD34(+) cells, the hematopoietic/endothelial progenitor cell-enriched population, in patients with fracture has never been reported. Here, we report the first case of tibial nonunion receiving autologous, granulocyte colony stimulating factor mobilized CD34(+) cells accompanied with autologous bone grafting. No serious adverse event occurred, and the novel therapy performed 9 months after the primary operation resulted in bone union 3 months later without any symptoms including pain and gait disturbance.
虽然将粗制骨髓细胞植入已经应用于少数骨折愈合患者，但外周血 CD34(+)细胞（富含造血/内皮祖细胞）在骨折患者中的移植从未有过报道。在这里，我们报告首例接受自体粒细胞集落刺激因子动员的 CD34(+)细胞联合自体骨移植治疗的胫骨骨不连患者。没有发生严重不良事件，新的治疗方法在初次手术后 9 个月进行，3 个月后就实现了骨愈合，没有出现任何症状，包括疼痛和步态障碍。
