Cheng Juan, Du Yu-tang, Ding Hua-ye
Department of Pathology, Dongzhimen Hospital, Beijing University of Chinese Medical Science, Beijing 100700, China.
Zhonghua Bing Li Xue Za Zhi. 2010 Oct;39(10):678-80.
To study the clinical and pathologic features of granulomatous lobular mastitis (GLM).
Sixty-eight cases of GLM were retrieved from the archival file. The clinical data and histologic features were retrospectively reviewed.
Sixty-eight patients presented with breast mass. Ulceration in overlying breast skin was seen in 9 cases. Most of the patients had history of breast feeding. None of them had evidence of specific infections involving the breast. The clinical and radiologic features mimicked malignancy. Histologically, GLM was characterized by the presence of non-necrotizing granulomas, usually admixed with neutrophils and associated with benign ductolobular units. The ductolobular architecture was still preserved. The duration of follow up ranged from 6 to 36 months. Four patients suffered from disease recurrence.
GLM shows clinical and radiologic features reminiscent of breast cancer. Correct diagnosis requires histologic examination of the biopsy specimens.
研究肉芽肿性小叶性乳腺炎（GLM）的临床及病理特征。
从存档文件中检索出68例GLM病例。对其临床资料和组织学特征进行回顾性分析。
68例患者均表现为乳腺肿块。9例患者乳腺皮肤出现溃疡。大多数患者有哺乳史。均无乳腺特异性感染证据。其临床及影像学特征类似恶性肿瘤。组织学上，GLM的特征为存在非坏死性肉芽肿，通常混有中性粒细胞，并与良性导管小叶单位相关。导管小叶结构仍保留。随访时间为6至36个月。4例患者疾病复发。
GLM的临床及影像学特征易让人联想到乳腺癌。正确诊断需要对活检标本进行组织学检查。
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