Donn W, Rebbeck P, Wilson C, Gilks C B
Department of Pathology, University Hospital, University of British Columbia, Vancouver.
Arch Pathol Lab Med. 1994 Aug;118(8):822-5.
We report three cases of idiopathic granulomatous mastitis that occurred in women of reproductive age (range, 25 to 36 years). These patients presented with breast masses of 2.5, 7, and 10 cm. One patient also had erythema nodosum. On biopsy specimens, the characteristic histopathologic features of granulomatous inflammation, centered on mammary lobules, were present in each case. In only one case was a specific diagnosis of granulomatous mastitis rendered based on the results of the biopsy; this patient received oral prednisone with prompt shrinkage of the breast mass to 20% of its original size. This residual mass was then resected. The remaining two patients were observed after biopsies were performed, with one experiencing a local recurrence after 5 weeks. The optimal therapy for idiopathic granulomatous mastitis has not been established, and we discuss treatment options, based on these three cases and those previously reported.
我们报告了3例发生在育龄女性（年龄范围为25至36岁）的特发性肉芽肿性乳腺炎病例。这些患者的乳房肿块大小分别为2.5厘米、7厘米和10厘米。其中1例患者还出现了结节性红斑。在活检标本中，每例均呈现以乳腺小叶为中心的肉芽肿性炎症的特征性组织病理学表现。仅1例根据活检结果作出了肉芽肿性乳腺炎的明确诊断；该患者接受口服泼尼松治疗后，乳房肿块迅速缩小至原来大小的20%。随后切除了残留肿块。其余2例患者在活检后进行观察，其中1例在5周后出现局部复发。特发性肉芽肿性乳腺炎的最佳治疗方法尚未确定，我们根据这3例病例以及先前报道的病例讨论了治疗选择。
