Cheng Juan, Ding Hua-ye, DU Yu-tang
Department of Pathology, Dongzhimen Hospital, Beijing University of Chinese Medical Science, Beijing 100700, China. E-mail:
Zhonghua Bing Li Xue Za Zhi. 2013 Oct;42(10):665-8.
To study the clinicopathologic features of granulomatous lobular mastitis and mammary duct ectasia.
The clinicopathologic data from August 2005 to May 2013 of 32 cases of granulomatous lobular mastitis and mammary duct ectasia were retrospectively reviewed.
The age of patients ranged from 26 to 45 years. Two patients had no history of delivery. Fourteen patients had no history of lactation or lactational disorder in the lesional side. Most of the remaining patients had history of breast feeding. Gross examination showed that the lesions were poorly circumscribed and varied from 3 to 12 cm in greatest dimension. Tiny abscess cavities, ranging from 0.1 to 0.5 cm in diameter and containing light yellowish to greyish secretion, were demonstrated. Histologic examination showed granuloma formation and ductal dilatation. Eleven patients had received antibiotic treatment. Twelve cases were complicated by sinus formation related to skin incision and drainage. The duration of follow-up ranged from 5 to 90 months. Three cases showed ipsilateral recurrence and 3 cases had similar pathology in the contralateral breast. Four patients defaulted follow-up.
Granulomatous lobular mastitis is associated with mammary duct ectasia. Accurate pathologic diagnosis is prudent for clinical management and control of local recurrence.
研究肉芽肿性小叶性乳腺炎和乳腺导管扩张症的临床病理特征。
回顾性分析2005年8月至2013年5月间32例肉芽肿性小叶性乳腺炎和乳腺导管扩张症的临床病理资料。
患者年龄26～45岁。2例患者无分娩史。14例患者病变侧无哺乳或泌乳紊乱史。其余大多数患者有母乳喂养史。大体检查显示病变边界不清，最大径3～12 cm。可见微小脓肿腔，直径0.1～0.5 cm，内含淡黄色至灰白色分泌物。组织学检查显示有肉芽肿形成和导管扩张。11例患者接受过抗生素治疗。12例因皮肤切开引流并发窦道形成。随访时间5～90个月。3例同侧复发，3例对侧乳腺有类似病理改变。4例失访。
肉芽肿性小叶性乳腺炎与乳腺导管扩张症相关。准确的病理诊断对临床治疗及控制局部复发至关重要。
