Li Chang-Dong, Zhang Wei-Yuan, Wu Ming-Hui, Zhang Song-Wen, Zhou Bao-Li, Zhu Li, Pan Jing, Wang Jian-Dong
Department of Gynecology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.
Zhonghua Fu Chan Ke Za Zhi. 2010 Oct;45(10):757-61.
to investigate high risk factors associated with cervical intraepithelial neoplasia (CIN) in married women aged 25 to 54 years in Beijing.
from Mar. 2007 to Sep. 2008, 6339 married women at age of 25 to 54 years were selected randomly by cross sectional survey in a total of 137 communities of 12 districts or counties in Beijing. The interview was carried out with unified questionnaires, gynecological examination. The cervical smear cytology and high-risk human papillomavirus (HR-HPV) infection of cervical secretion were detected. Women with abnormal cervical cytology underwent colposcopy and cervical biopsy. Odd ratio (OR) and 95% confidence interval (CI) of related high risk factors with CIN were studied by logistic regression analysis.
among 6339 women, the prevalence rate of CIN including 4 squamous cell carcinoma (SCC) was 5.90% (374/6339). By multinomial regression analysis, HR-HPV infection (95%CI: 9.953 - 15.811), History of trichomonas vaginitis (95%CI: 1.046 - 2.104), oral contraceptives (95%CI: 1.087 - 1.806), age less than 45 years old (95%CI: 1.069 - 1.828) were related with CIN.
infection rate of HR-HPV is an independent risk factor of CIN, however, the history of trichomonas vaginitis, oral contraceptives and age less than 45 years old are related risk factors of CIN.
调查北京地区25至54岁已婚女性宫颈上皮内瘤变（CIN）的相关高危因素。
2007年3月至2008年9月，采用横断面调查方法，在北京12个区县的137个社区随机选取6339名25至54岁的已婚女性。采用统一问卷进行访谈，并进行妇科检查。检测宫颈涂片细胞学及宫颈分泌物高危型人乳头瘤病毒（HR-HPV）感染情况。宫颈细胞学异常的女性接受阴道镜检查及宫颈活检。采用logistic回归分析研究CIN相关高危因素的比值比（OR）及95%置信区间（CI）。
6339名女性中，CIN患病率（包括4例鳞状细胞癌）为5.90%（374/6339）。多因素回归分析显示，HR-HPV感染（95%CI：9.953 - 15.811）、滴虫性阴道炎病史（95%CI：1.046 - 2.104）、口服避孕药（95%CI：1.087 - 1.806）、年龄小于45岁（95%CI：1.069 - 1.828）与CIN有关。
HR-HPV感染率是CIN的独立危险因素，而滴虫性阴道炎病史、口服避孕药及年龄小于45岁是CIN的相关危险因素。
