Wu Ming-hui, Zhang Song-wen, Zhang Wei-yuan, Zhou Bao-li, Xie Zheng, Wang Jian-dong, Dai Yin-mei
Department of Health Care, Department of Obstetrics, Department of Gynecologic Oncology and Gynecologic Minimal Invasive Center, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2010 Feb;31(2):133-7.
To investigate the prevalence and relationship between high risk human papillomavirus (HR-HPV) and cervical intraepithelial neoplasia (CIN) in married women from Beijing.
From March 2007 to September 2008, a total of 6185 married women were sampled, covering 137 communities in 12 districts. The samples were screened by high-risk HPV DNA test (HC2) and cytological test. For those participants with cytological test results ≥ ASCUS, pathological tests were performed. An interview was also carried out with the same questionnaire. Results from the tests were inputted into the database twice using EpiData 3.0, reviewed, analyzed, using SPSS 15.0.
(1) The prevalence rates of HR-HPV and CIN were 9.9% and 6.0%, respectively for the age group 25 to 54. (2) The peak age groups for HR-HPV and CIN prevalence rates were 30 to 34 years old. (3) The prevalence rates of positive cytology (40.3%) and CIN (30.4%) in HR-HPV positive female population were significantly higher than that in HR-HPV negative group. (4) Data from unconditional logistic regression analysis showed that, when comparing with the normal subjects, the risk odds ratios of HR-HPV with low grade CIN and cervical cancer/high grade CIN were 8.385 and 97.416 and the attributable risk proportions with these groups were 88.1% and 99.0%, respectively.
HR-HPV infection seemed to be the main risk factor for CIN. Married women, from age group 30 - 34, were under the high risk group in both HR-HPV infection and CIN incidence.
调查北京已婚女性高危型人乳头瘤病毒（HR-HPV）感染率及其与宫颈上皮内瘤变（CIN）的关系。
2007年3月至2008年9月，共抽取6185名已婚女性作为样本，覆盖12个区的137个社区。样本采用高危型HPV DNA检测（HC2）和细胞学检测进行筛查。对细胞学检测结果≥非典型鳞状细胞不能明确意义（ASCUS）的参与者进行病理检查。同时使用相同问卷进行访谈。检测结果使用EpiData 3.0软件录入数据库两次，并采用SPSS 15.0软件进行审核、分析。
（1）25至54岁年龄组HR-HPV和CIN的感染率分别为9.9%和6.0%。（2）HR-HPV和CIN感染率的高峰年龄组为30至34岁。（3）HR-HPV阳性女性人群中细胞学阳性率（40.3%）和CIN发生率（30.4%）显著高于HR-HPV阴性组。（4）非条件logistic回归分析数据显示，与正常受试者相比，HR-HPV感染低级别CIN和宫颈癌/高级别CIN的风险比值分别为8.385和97.416，与这些组的归因风险比例分别为88.1%和99.0%。
HR-HPV感染似乎是CIN的主要危险因素。30至34岁的已婚女性是HR-HPV感染和CIN发病的高危人群。
