Zhao Xi-zhen, Guan Ze-min, Zhang Yan-min
Department of Stomatology, Henan Provincial People's Hospital, Zhengzhou 450003, China.
Zhonghua Kou Qiang Yi Xue Za Zhi. 2010 Oct;45(10):610-3.
To investigate the relationship between transforming growth factor beta-1 (TGF-β(1)) gene-509C/T polymorphism and severe chronic periodontitis in Chinese Hans population.
TGF-β(1)-509C/T genotype polymorphism was analyzed in 102 patients with severe chronic periodontitis (periodontitis group) and 102 healthy controls (control group) by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method.
The distributions of TGF-β(1)-509C/T genotype and allele were significantly different between severe chronic periodontitis group and control group (P < 0.05). TGF-β(1)-509CC, CT and TT genotype frequency were 44.1% (45/102), 47.1% (48/102), 8.8% (9/102) in periodontitis group and 29.4% (30/102), 51.0% (52/102), 19.6% (20/102) in control group, respectively. The relative risk analysis found that C allele carriers had higher risk of suffering from severe chronic periodontitis compared with T allele carriers (OR = 1.718, 95%CI: 1.148-2.569).
TGF-β(1)-509C/T polymorphism is associated with severe chronic periodontitis in Chinese Hans population, and C allele may be an important genetic susceptibility gene for severe chronic periodontitis.
探讨转化生长因子β-1（TGF-β(1)）基因-509C/T多态性与中国汉族人群重度慢性牙周炎的关系。
采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法，对102例重度慢性牙周炎患者（牙周炎组）和102例健康对照者（对照组）进行TGF-β(1)-509C/T基因型多态性分析。
重度慢性牙周炎组与对照组TGF-β(1)-509C/T基因型及等位基因分布差异有统计学意义（P < 0.05）。牙周炎组TGF-β(1)-509CC、CT和TT基因型频率分别为44.1%（45/102）、47.1%（48/102）、8.8%（9/102），对照组分别为29.4%（30/102）、51.0%（52/102）、19.6%（20/102）。相对危险度分析发现，与T等位基因携带者相比，C等位基因携带者患重度慢性牙周炎的风险更高（OR = 1.718，95%CI：1.148 - 2.569））。
TGF-β(1)-509C/T多态性与中国汉族人群重度慢性牙周炎相关，C等位基因可能是重度慢性牙周炎的重要遗传易感基因。
