Cui Lei, Sun Ya-Ping, Li Da-Gang, Wang Shao-Hua, Shao Dan
Department of Stomatology, Qingdao Economic and Technological Development Area First People's Hospital Whampoa Jiang Road 7, Qingdao 266555, Shandong, China.
Int J Clin Exp Med. 2015 Sep 15;8(9):15569-74. eCollection 2015.
The association between TGF-β1 rs1800469 polymorphism and the risk of periodontitis was controversial and inconclusive. This meta-analysis aimed to evaluate the association between the TGF-β1 rs1800469 polymorphism and periodontitis risk. The electronic databases PubMed, EMBASE, and Web of Science were searched for studies to include in the present meta-analysis. Odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of association between the TGF-β1 rs1800469 polymorphism and periodontitis risk. A total of 8 publications involving 923 cases and 892 controls met the inclusion criteria and were ultimately analyzed. In this meta-analysis, a significant association was detected between TGF-β1 rs1800469 polymorphism and periodontitis risk (OR=1.21; 95% CI, 1.05-1.39; P=0.008). In the subgroup analysis by ethnicity, the significant association was only found among Asians (OR=1.23; 95% CI, 1.05-1.44; P=0.01), while no significant association was found among Caucasians (OR=1.16; 95% CI, 0.90-1.49; P=0.25). In the subgroup analysis by type and periodontitis, the significant association was only found among CP patients (OR=1.18; 95% CI, 1.02-1.37; P=0.03), while no significant association was found among AP patients (OR=1.27; 95% CI, 0.98-1.65; P=0.07). In addition, no significant association was found among non-smokers (OR=1.28; 95% CI, 0.93-1.76; P=0.13). In conclusion, this meta-analysis suggests that the TGF-β1 rs1800469 polymorphism is associated with periodontitis risk. Further studies analyzing gene-gene and gene-environment interactions are required.
转化生长因子-β1（TGF-β1）rs1800469基因多态性与牙周炎风险之间的关联存在争议且尚无定论。本荟萃分析旨在评估TGF-β1 rs1800469基因多态性与牙周炎风险之间的关联。通过检索电子数据库PubMed、EMBASE和Web of Science来查找纳入本荟萃分析的研究。采用比值比（OR）及95%置信区间（CI）来评估TGF-β1 rs1800469基因多态性与牙周炎风险之间关联的强度。共有8篇涉及923例病例和892例对照的文献符合纳入标准并最终进行分析。在本荟萃分析中，检测到TGF-β1 rs1800469基因多态性与牙周炎风险之间存在显著关联（OR = 1.21；95% CI，1.05 - 1.39；P = 0.008）。在按种族进行的亚组分析中，仅在亚洲人中发现显著关联（OR = 1.23；95% CI，1.05 - 1.44；P = 0.01），而在白种人中未发现显著关联（OR = 1.16；95% CI，0.90 - 1.49；P = 0.25）。在按牙周炎类型进行的亚组分析中，仅在慢性牙周炎（CP）患者中发现显著关联（OR = 1.18；95% CI，1.02 - 1.37；P = 0.03），而在侵袭性牙周炎（AP）患者中未发现显著关联（OR = 1.27；95% CI，0.98 - 1.65；P = 0.07）。此外，在非吸烟者中未发现显著关联（OR = 1.28；95% CI，0.93 - 1.76；P = 0.13）。总之，本荟萃分析表明TGF-β1 rs1800469基因多态性与牙周炎风险相关。需要进一步开展分析基因 - 基因和基因 - 环境相互作用的研究。
