Tanguy-Goarin Charlotte, Cogulet Virginie
Pôle Pharmacie, Hôpital Morvan, CHRU Brest, 2 avenue Foch, 29609 Brest Cedex, France.
Therapie. 2010 Nov-Dec;65(6):525-31. doi: 10.2515/therapie/2010066. Epub 2010 Dec 23.
Drugs delivery by subcutaneous injection is often the last resort/appeal for a doctor anxious to limit the aggressive and invasive treatments, particularly within palliative care. A review was made to list the drugs which can be administered by this route. Concerned antibiotics are teicoplanin, netilmicin and gentamicin with a risk of skin necrosis for aminoglycosids. Midazolam is useful in various indications and can be associated with morphine in case of dyspnoea. Data about subcutaneous injection of dexamethasone, clonazepam, haloperidol and levomepromazine are published; it is the same for fentanyl, nefopam, ondansetron and metoclopramide. The subcutaneous injection of these quoted drugs is possible, but requires further studies.
对于急于限制积极且侵入性治疗的医生而言，皮下注射给药往往是最后的手段，尤其是在姑息治疗中。进行了一项综述以列出可通过该途径给药的药物。相关抗生素有替考拉宁、奈替米星和庆大霉素，氨基糖苷类有导致皮肤坏死的风险。咪达唑仑适用于多种适应症，在出现呼吸困难时可与吗啡联用。关于地塞米松、氯硝西泮、氟哌啶醇和左美丙嗪皮下注射的数据已发表；芬太尼、奈福泮、昂丹司琼和甲氧氯普胺也是如此。这些列举药物的皮下注射是可行的，但需要进一步研究。
