Entezami Pouya, Fox David A, Clapham Philip J, Chung Kevin C
Section of Plastic Surgery, University of Michigan Health System, 2130 Taubman Center, SPC 5340, 1500 East Medical Center Drive, Ann Arbor, MI 48109-5340, USA.
Hand Clin. 2011 Feb;27(1):1-10. doi: 10.1016/j.hcl.2010.09.006.
Contributions of historical analyses to the development of a cogent etiologic theory of rheumatoid arthritis (RA) have been limited to date. In this article, the authors analyze this literature with respect to the types and conclusions of the research that has been conducted, present the major points of evidence and conclusions that have been drawn, and trace the evolution of 3 historical theories of RA. The authors combine a comprehensive overview of paintings and paleopathological investigations with consideration of contemporary immunologic and genetic studies.
迄今为止,历史分析对类风湿关节炎(RA)有说服力的病因学理论发展的贡献有限。在本文中,作者针对已开展研究的类型和结论对该文献进行分析,呈现已得出的主要证据要点和结论,并追溯RA三个历史理论的演变。作者将绘画和古病理学研究的全面概述与当代免疫学和遗传学研究的考量结合起来。