伦勃朗画作中的玛丽亚·博克诺勒有蝶形红斑和手指畸形：类风湿关节炎与系统性红斑狼疮重叠综合征。

Rembrandt's Maria Bockenolle has a butterfly rash and digital deformities: overlapping syndrome of rheumatoid arthritis and systemic lupus erythematosus.

作者信息

Hayakawa Satoshi, Komine-Aizawa Shihoko, Osaka Shunzo, Iida Toshihiro, Hayakawa Junko, Nishinarita Susumu, Nemoto Norimichi

机构信息

Division of Infectious Disease Control and Clinical Immunology, Nihon University Medical Research Institute, 30-1 Ohyaguchi-kamimachi, Itabashiku, Tokyo 173-8610, Japan.

出版信息

Med Hypotheses. 2007;68(4):906-9. doi: 10.1016/j.mehy.2006.09.055. Epub 2006 Nov 17.

DOI:10.1016/j.mehy.2006.09.055

PMID:17113236

Abstract

Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are the most common autoimmune disorders, although they each have very different pathophysiology. In general, RA is considered to be a Th1-mediated disease, while SLE is a Th2-mediated disease. Thus, their overlapping, in so called "rhupus", is a rare condition. In Rembrandt van Rijn's (1606-1669) portrait of the middle-aged Maria Bockenolle, we have what may be the earliest depiction of a case of rhupus syndrome: the coexistence of a butterfly rash and digital deformities. This suggests the possible historical importance of an RA epidemic which took place in the early 17th century.

摘要

类风湿性关节炎（RA）和系统性红斑狼疮（SLE）是最常见的自身免疫性疾病，尽管它们各自的病理生理学有很大差异。一般来说，RA被认为是一种由Th1介导的疾病，而SLE是一种由Th2介导的疾病。因此，它们在所谓的“rhupus”中的重叠是一种罕见的情况。在伦勃朗·范·莱因（1606 - 1669）为中年玛丽亚·博克诺勒绘制的肖像画中，我们看到了可能是rhupus综合征病例的最早描绘：蝶形红斑和手指畸形并存。这表明17世纪初发生的一场RA流行病可能具有重要的历史意义。