Center for Eukaryotic Gene Regulation, Department of Biochemistry & Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA.
Curr Opin Struct Biol. 2011 Feb;21(1):128-36. doi: 10.1016/j.sbi.2010.11.006. Epub 2010 Dec 19.
Chromatin plays a fundamental role in eukaryotic genomic regulation, and the increasing awareness of the importance of epigenetic processes in human health and disease emphasizes the need for understanding the structure and function of the nucleosome. Recent advances in chromatin structural studies, including the first structures of nucleosomes containing the Widom 601 sequence and the structure of a chromatin protein-nucleosome assembly, have provided new insight into stretching of nucleosomal DNA, nucleosome positioning, binding of metal ions, drugs and therapeutic candidates to nucleosomes, and nucleosome recognition by nuclear proteins. These discoveries ensure promising future prospects for unravelling structural attributes of chromatin.
染色质在真核基因组调控中起着至关重要的作用，人们越来越意识到表观遗传过程在人类健康和疾病中的重要性，这强调了需要了解核小体的结构和功能。染色质结构研究的最新进展，包括含有威道姆 601 序列的核小体和染色质蛋白-核小体组装结构的首次结构，为核小体 DNA 的拉伸、核小体定位、金属离子、药物和治疗候选物与核小体的结合以及核蛋白对核小体的识别提供了新的见解。这些发现为揭示染色质的结构属性提供了有希望的未来前景。
