Department of Pediatrics, University of Gothenburg, Sweden.
Prostaglandins Leukot Essent Fatty Acids. 2011 Mar-Apr;84(3-4):85-92. doi: 10.1016/j.plefa.2010.11.002. Epub 2010 Dec 21.
Our objective was to investigate the long-term metabolic effects of postnatal essential fatty acid deficiency (EFAD). Mouse dams were fed an EFAD diet or an isoenergetic control diet 4 days before delivery and throughout lactation. The pups were weaned to standard diet (STD) and were later subdivided into two groups: receiving high fat diet (HFD) or STD. Body composition, energy expenditure, food intake and leptin levels were analyzed in adult offspring. Blood glucose and plasma insulin concentrations were measured before and during a glucose tolerance test. EFAD offspring fed STD were leaner with lower plasma leptin and insulin concentrations compared to controls. EFAD offspring fed HFD were resistant to diet-induced obesity, had higher energy expenditure and lower levels of plasma leptin and insulin compared to controls. These results indicate that the fatty acid composition during lactation is important for body composition and glucose tolerance in the adult offspring.
我们的目的是研究产后必需脂肪酸缺乏（EFAD）的长期代谢影响。在分娩前 4 天和哺乳期，鼠母鼠喂食 EFAD 饮食或等能量对照饮食。幼崽断奶后接受标准饮食（STD），随后分为两组：接受高脂肪饮食（HFD）或 STD。分析成年后代的身体成分、能量消耗、食物摄入和瘦素水平。在葡萄糖耐量试验之前和期间测量血糖和血浆胰岛素浓度。与对照组相比，喂食 STD 的 EFAD 后代更瘦，血浆瘦素和胰岛素浓度更低。与对照组相比，喂食 HFD 的 EFAD 后代对饮食诱导的肥胖具有抗性，能量消耗更高，血浆瘦素和胰岛素水平更低。这些结果表明，哺乳期的脂肪酸组成对成年后代的身体成分和葡萄糖耐量很重要。
