Zwingenberger K, Richter J, Vergetti J G, Feldmeier H
Landesinstitut für Tropenmedizin Berlin, Federal Republic of Germany.
Trans R Soc Trop Med Hyg. 1990 Mar-Apr;84(2):252-6. doi: 10.1016/0035-9203(90)90277-l.
Serological indicators for disease activity and portal vein obstruction and/or deviation were assessed in 23 patients with hepatosplenic schistosomiasis before, and up to 18 months after, praziquantel treatment, as well as in 25 matched local controls. Cessation of egg-induced immunopathology was reflected by the return to normal of serum procollagen-III-propeptide and neopterin concentrations. Reversibility of portal vein pathology was indicated by normal clearance of cholylglycine in cases without signs of decompensating portal hypertension. In most patients with a history of ascites and/or haemorrhage, serum cholylglycine concentration remained pathological. The results provide evidence that the fibrogenic process ceases after specific chemotherapy, and that portal vein pathology regresses in a substantial proportion of hepatosplenic schistosomiasis cases.
在23例肝脾型血吸虫病患者中，于吡喹酮治疗前及治疗后长达18个月评估疾病活动、门静脉梗阻和/或门静脉偏离的血清学指标，同时纳入25例匹配的当地对照。血清前胶原III前肽和新蝶呤浓度恢复正常反映了虫卵诱导的免疫病理学的停止。在无门静脉高压失代偿迹象的病例中，胆酰甘氨酸清除正常表明门静脉病理改变具有可逆性。在大多数有腹水和/或出血病史的患者中，血清胆酰甘氨酸浓度仍处于病理状态。结果表明，特异性化疗后纤维化过程停止，且在相当一部分肝脾型血吸虫病病例中门静脉病理改变有所消退。
