McGill University, Center for Indigenous Peoples Nutrition and Environment, School of Dietetics and Human Nutrition, Ste Anne De Bellevue, Canada.
J Nutr. 2011 Feb;141(2):290-5. doi: 10.3945/jn.110.129619. Epub 2010 Dec 22.
Epidemiological studies report inverse associations between blood vitamin D, as measured by 25-hydroxyvitamin D [25(OH)D] concentrations, and insulin resistance (IR) among predominantly overweight individuals. In a cross-sectional survey of 5 Cree communities in Quebec, Canada, we determined if 25(OH)D is associated with IR and β-cell function in a largely obese, ethnic minority at high risk of developing type 2 diabetes. A total of 510 participants (≥18 y) without type 1 or type 2 diabetes, assessed for serum 25(OH)D, fasting plasma glucose and insulin, and anthropometric and lifestyle variables, were included in the analyses. Multivariable linear regressions adjusted for covariates were performed for homeostasis model assessment of IR (HOMA-IR) and β-cell function (HOMA-B) in relation to serum 25(OH)D. Serum 25(OH)D (per 10 nmol/L increment) was inversely associated with HOMA-IR (β = -0.005; SE = 0.002; P = 0.004) and HOMA-B (β = -0.004; SE = 0.002; P = 0.006) in models adjusted for age, sex, physical activity, education, alcohol consumption, and smoking. When further adjusted for BMI, associations were no longer significant for either HOMA-IR (β = 0.001, SE = 0.002, P = 0.572) or HOMA-B (β = 0.001, SE = 0.001, P = 0.498). The modest inverse associations between 25(OH)D and IR reported previously were not observed in this population after adjusting for adiposity. Future longitudinal studies investigating the interrelationship among 25(OH)D, adiposity, and the risk of developing metabolic syndrome and type 2 diabetes are warranted.
流行病学研究报告称，在主要超重人群中，血液维生素 D（通过 25-羟维生素 D [25(OH)D] 浓度测量）与胰岛素抵抗（IR）呈负相关。在加拿大魁北克的 5 个克里社区的横断面调查中，我们确定在一个以肥胖为主、种族少数群体、患 2 型糖尿病风险高的人群中，25(OH)D 是否与 IR 和β细胞功能有关。共有 510 名（≥18 岁）无 1 型或 2 型糖尿病的参与者，评估血清 25(OH)D、空腹血糖和胰岛素、人体测量和生活方式变量，纳入分析。对协变量进行多变量线性回归，以评估血清 25(OH)D 与稳态模型评估的 IR（HOMA-IR）和β细胞功能（HOMA-B）的关系。血清 25(OH)D（每增加 10 nmol/L）与 HOMA-IR（β=-0.005；SE=0.002；P=0.004）和 HOMA-B（β=-0.004；SE=0.002；P=0.006）呈负相关，在调整年龄、性别、体力活动、教育、饮酒和吸烟的模型中。当进一步调整 BMI 时，HOMA-IR（β=0.001，SE=0.002，P=0.572）或 HOMA-B（β=0.001，SE=0.001，P=0.498）的相关性不再显著。在调整肥胖后，在该人群中没有观察到先前报道的 25(OH)D 与 IR 之间的适度负相关。需要进行未来的纵向研究，以调查 25(OH)D、肥胖和代谢综合征和 2 型糖尿病发病风险之间的相互关系。
