Department of Epidemiology and the Program on Genomics and Nutrition, University of California, Los Angeles, Los Angeles, CA.
Am J Clin Nutr. 2011 Jul;94(1):209-17. doi: 10.3945/ajcn.110.010272. Epub 2011 May 25.
Low concentrations of serum 25-hydroxyvitamin D [25(OH)D] may be associated with cardiometabolic disorders; however, little is known about their relation to intermediate metabolic and lipid markers.
We investigated the relation of serum 25(OH)D concentrations to fasting insulin, glucose, dyslipidemia, adiposity, and prevalent metabolic syndrome.
We conducted this cross-sectional analysis in 292 postmenopausal women aged 50-79 y in the Women's Health Initiative Calcium-Vitamin D (WHI-CaD) trial. Data were collected from 3 nested case-control studies that measured baseline serum 25(OH)D concentrations. Inverse probability weighting was used to approximate parameter estimates for the WHI-CaD population.
In weighted linear regression models adjusted for age, race-ethnicity, month of blood draw, region, case-control status, smoking, alcohol, physical activity, and history of cardiometabolic risk factors, there was an inverse association of serum 25(OH)D with adiposity [body mass index (BMI): β = -1.12 ± 0.30, P = 0.0002; waist circumference: β = -3.57 ± 0.49, P < 0.0001; waist-hip ratio: β = -0.01 ± 0.002, P < 0.0001], triglycerides (β = -0.10 ± 0.02, P < 0.0001), and triglyceride:HDL-cholesterol ratio (β = -0.11 ± 0.03, P = 0.0003). The multivariable-adjusted odds ratio for metabolic syndrome for the highest (≥52 nmol/L) compared with the lowest (<35 nmol/L) tertile of serum 25(OH)D concentrations was 0.28 (95% CI: 0.14, 0.56). Significant associations remained after adjustment for BMI. We observed no significant associations with LDL cholesterol, HDL cholesterol, insulin, glucose, homeostatic model assessment of insulin resistance (HOMA-IR), or homeostatic model assessment of β cell function (HOMA-β).
Higher serum 25(OH)D concentrations may be inversely associated with adiposity, triglycerides, triglyceride:HDL-cholesterol ratio, and metabolic syndrome but are not associated with LDL and HDL cholesterol, insulin, glucose, HOMA-IR, or HOMA-β in postmenopausal women. This trial was registered at clinicaltrials.gov as NCT00000611.
血清 25-羟维生素 D [25(OH)D]浓度较低可能与心血管代谢紊乱有关；然而，关于其与中间代谢和脂质标志物的关系知之甚少。
我们研究了血清 25(OH)D 浓度与空腹胰岛素、血糖、血脂异常、肥胖和常见代谢综合征的关系。
我们在 292 名年龄在 50-79 岁的绝经后妇女中进行了这项横断面分析，这些妇女参加了妇女健康倡议钙-维生素 D（WHI-CaD）试验。数据来自 3 项嵌套病例对照研究，这些研究测量了基线血清 25(OH)D 浓度。采用逆概率加权法近似 WHI-CaD 人群的参数估计值。
在调整年龄、种族-民族、采血月份、地区、病例对照状态、吸烟、饮酒、体力活动和心血管代谢危险因素史的加权线性回归模型中，血清 25(OH)D 与肥胖[体重指数（BMI）：β=-1.12±0.30，P=0.0002；腰围：β=-3.57±0.49，P<0.0001；腰围-臀围比：β=-0.01±0.002，P<0.0001]、甘油三酯（β=-0.10±0.02，P<0.0001）和甘油三酯：高密度脂蛋白胆固醇比值（β=-0.11±0.03，P=0.0003）呈负相关。与血清 25(OH)D 浓度最低（<35 nmol/L）三分位组相比，最高（≥52 nmol/L）三分位组的代谢综合征的多变量校正比值比为 0.28（95%CI：0.14，0.56）。调整 BMI 后，相关性仍然显著。我们没有观察到与 LDL 胆固醇、HDL 胆固醇、胰岛素、血糖、胰岛素抵抗稳态模型评估（HOMA-IR）或胰岛β细胞功能稳态模型评估（HOMA-β）之间存在显著关联。
绝经后妇女血清 25(OH)D 浓度较高可能与肥胖、甘油三酯、甘油三酯：高密度脂蛋白胆固醇比值和代谢综合征呈负相关，但与 LDL 和 HDL 胆固醇、胰岛素、血糖、HOMA-IR 或 HOMA-β无相关性。该试验在 clinicaltrials.gov 上注册为 NCT00000611。
