热休克调控在人类真菌病原体中的相关性。
The relevance of heat shock regulation in fungal pathogens of humans.
机构信息
Aberdeen Fungal Group, School of Medical Sciences, University of Aberdeen, Aberdeen, UK.
出版信息
Virulence. 2010 Jul-Aug;1(4):330-2. doi: 10.4161/viru.1.4.12364.
Abstract
Despite being obligately associated with warm-blooded animals, Candida albicans expresses a bona fide heat shock response that is regulated by the evolutionarily conserved, essential heat shock transcription factor Hsf1. Hsf1 is thought to play a fundamental role in thermal homeostasis, adjusting the levels of essential chaperones to changes in growth temperature, for example in febrile patients. Hsf1 also regulates the expression of Hsp90, which controls the yeast-hypha transition in C. albicans, and we argue, might also control morphogenesis in other fungal pathogens of humans.
摘要
尽管白色念珠菌必然与温血动物相关联，但它表达了一种真正的热休克反应，该反应受进化上保守的必需热休克转录因子 Hsf1 调控。Hsf1 被认为在体温平衡中发挥着基本作用，例如在发烧患者中，它可以调节必需伴侣蛋白的水平以适应生长温度的变化。Hsf1 还调节 Hsp90 的表达，Hsp90 控制白色念珠菌中的酵母-菌丝过渡，我们认为，它也可能控制其他人类真菌病原体的形态发生。
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