Znaidi Sadri
Institut Pasteur de Tunis, University of Tunis El Manar, Laboratoire de Microbiologie Moléculaire, Vaccinologie et Développement Biotechnologique, Tunis, Tunisia.
Institut Pasteur, INRA, Département Mycologie, Unité Biologie et Pathogénicité Fongiques, Paris, France.
mSphere. 2025 Jan 28;10(1):e0064423. doi: 10.1128/msphere.00644-23. Epub 2024 Dec 20.
Heat shock factor (HSF)-type regulators are stress-responsive transcription factors widely distributed among eukaryotes, including fungi. They carry a four-stranded winged helix-turn-helix DNA-binding domain considered as the signature domain for HSFs. The genome of the opportunistic yeast encodes four HSF members, namely, Sfl1, Sfl2, Skn7, and the essential regulator, Hsf1. HSFs do not only respond to heat shock and/or temperature variation but also to CO levels, oxidative stress, and quorum sensing, acting this way as central decision makers. In this minireview, I follow on the heels of my mSphere of Influence commentary (2020) to provide an overview of the repertoire of HSF regulators in and and describe how their genetic perturbation in , coupled with genome-wide expression and location analyses, allow to map their transcriptional circuitry. I highlight how they can regulate, in common, a crucial developmental program: filamentous growth.
热休克因子（HSF）型调节因子是广泛分布于包括真菌在内的真核生物中的应激反应转录因子。它们携带一个四链翼状螺旋-转角-螺旋DNA结合结构域，该结构域被认为是HSF的标志性结构域。机会性酵母的基因组编码四个HSF成员，即Sfl1、Sfl2、Skn7和必需调节因子Hsf1。HSF不仅对热休克和/或温度变化有反应，而且对一氧化碳水平、氧化应激和群体感应也有反应，以这种方式充当核心决策者。在这篇小型综述中，我紧跟我在《mSphere of Influence》（2020年）中的评论，概述了[具体物种1]和[具体物种2]中HSF调节因子的全部情况，并描述了它们在[具体物种3]中的基因扰动，以及全基因组表达和定位分析如何有助于绘制它们的转录调控网络。我强调了它们如何共同调节一个关键的发育程序：丝状生长。
