Department of epidemiology, School of Radiation Medicine and Public Health, Medical College of Soochow University, Suzhou, PR China.
Hypertens Res. 2011 Apr;34(4):516-20. doi: 10.1038/hr.2010.255. Epub 2010 Dec 23.
Chronic inflammation and endothelial dysfunction may be associated with hypertension and cardiovascular disease. We examined associations between inflammatory and endothelial dysfunction biomarkers and the risk of prehypertension among Mongolians. A cross-sectional study was conducted among 2589 Mongolians aged 20 years and older in Inner Mongolia, China. Three blood pressure measurements, body weight, height and lifestyle factors were obtained for all participants. Overnight fasting blood samples were obtained to measure the biomarkers, including C-reactive protein (CRP), soluble intercellular adhesion molecule-1 (sICAM-1), soluble E-selectin (sE-selectin) and angiotensin II. The average levels of CRP (7.43 vs. 5.86), sICAM-1 (339.38 vs. 328.05), sE-selectin (19.11 vs. 18.32) and angiotensin II (52.00 vs. 47.00) were all significantly higher in hypertensives than that in prehypertensives (all P<0.05); prehypertensives had higher levels of CRP (5.86 vs. 4.85) and sICAM-1 (328.05 vs. 314.14) compared with normotensives (both P<0.05). Hypertension (odds ratio (OR): 1.50, 95% confidence interval (CI): 1.07, 2.11) and prehypertension (OR: 1.38, 95% CI: 1.02, 1.85) were positively and significantly associated with elevated CRP adjusted for multivariable. Hypertension (OR: 1.56, 95% CI: 1.18, 2.06) and prehypertension (OR: 1.32, 95% CI: 1.02, 1.71) were also positively and significantly associated with higher sICAM-1 adjusted for age and gender. Elevated CRP and sICAM-1 were associated with prehypertension among Mongolian population. This study suggests that inflammation and endothelial dysfunction may have a role in the development of hypertension.
慢性炎症和内皮功能障碍可能与高血压和心血管疾病有关。我们研究了炎症和内皮功能障碍生物标志物与蒙古族人群发生高血压前期的风险之间的关系。在内蒙古进行了一项横断面研究，共纳入 2589 名年龄在 20 岁及以上的蒙古族人群。所有参与者均接受了三次血压测量、体重、身高和生活方式因素的测量。采集过夜禁食血样以测量生物标志物，包括 C 反应蛋白（CRP）、可溶性细胞间黏附分子-1（sICAM-1）、可溶性 E-选择素（sE-selectin）和血管紧张素 II。高血压患者的 CRP（7.43 比 5.86）、sICAM-1（339.38 比 328.05）、sE-selectin（19.11 比 18.32）和血管紧张素 II（52.00 比 47.00）的平均水平均显著高于高血压前期患者（均 P<0.05）；高血压前期患者的 CRP（5.86 比 4.85）和 sICAM-1（328.05 比 314.14）水平高于血压正常者（均 P<0.05）。经多变量调整后，高血压（比值比（OR）：1.50，95%置信区间（CI）：1.07，2.11）和高血压前期（OR：1.38，95%CI：1.02，1.85）与 CRP 升高呈正相关且有统计学意义。经年龄和性别调整后，高血压（OR：1.56，95%CI：1.18，2.06）和高血压前期（OR：1.32，95%CI：1.02，1.71）也与 sICAM-1 升高呈正相关且有统计学意义。在蒙古族人群中，CRP 和 sICAM-1 升高与高血压前期相关。本研究提示炎症和内皮功能障碍可能在高血压的发生发展中起作用。
