Zhang Mingzhi, Wang Guiyan, Wang Aili, Tong Weijun, Zhang Yonghong
Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou 215123, China.
Blood Press. 2013 Jun;22(3):151-7. doi: 10.3109/08037051.2012.745226. Epub 2012 Dec 4.
To explore association of hypertension with coexistence of inflammation and endothelial dysfunction and abnormal metabolism, a community-based study was conducted among Mongolian people in China. Demographic characteristics and lifestyle risk factors were investigated, blood pressure, body weight and waist circumference were measured, fasting blood samples were obtained to measure blood lipids, fasting plasma glucose and the biomarkers of inflammation and endothelial dysfunction, C-reactive protein (CRP), soluble intercellular cell adhesion molecule-1 (sICAM-1), soluble E-selectin (sE-selectin) and angiotensin II. Rates of abnormal metabolism, elevated CRP, elevated sICAM-1, elevated sE-selectin and elevated angiotensin II as well as coexistence of abnormal metabolism with the elevated biomarkers were all higher in hypertensives than these in normotensives (all p < 0.01). Compared with subjects with normal metabolism and without any elevated biomarker, multivariate adjusted odds ratio (95% confidence interval) of hypertension associated with abnormal metabolism, elevated CRP, elevated sICAM-1, elevated sE-selectin, elevated angiotensin II, coexistences of abnormal metabolism with elevated CRP, elevated sICAM-1,elevated sE-selectin and elevated angiotensin II were 2.209 (1.594-3.062), 2.820 (1.992-3.992), 2.370 (1.665-3.374), 1.893 (1.331-2.691), 2.545 (1.793-3.612), 2.990 (2.102-4.252), 2.551 (1.775-3.667), 2.223 (1.544-3.220), 3.135 (2.185-4.519), respectively. In conclusion, this study indicated that inflammation and endothelial dysfunction was associated with hypertension and abnormal metabolism, and individuals with co-existence of abnormal metabolism with inflammation and endothelial dysfunction had higher risk of prevalent hypertension among Mongolian population. This study suggests that further study on treatment for hypertension patients with coexistence of abnormal metabolism with inflammation and endothelial dysfunction should be conducted in the near future.
为探讨高血压与炎症、内皮功能障碍及代谢异常共存之间的关联，在中国蒙古族人群中开展了一项基于社区的研究。调查了人口统计学特征和生活方式危险因素，测量了血压、体重和腰围，采集空腹血样以检测血脂、空腹血糖以及炎症和内皮功能障碍的生物标志物，即C反应蛋白（CRP）、可溶性细胞间黏附分子-1（sICAM-1）、可溶性E选择素（sE选择素）和血管紧张素II。高血压患者中代谢异常、CRP升高、sICAM-1升高、sE选择素升高、血管紧张素II升高的发生率以及代谢异常与生物标志物升高共存的发生率均高于血压正常者（均P<0.01）。与代谢正常且生物标志物均未升高的受试者相比，高血压与代谢异常、CRP升高、sICAM-1升高、sE选择素升高、血管紧张素II升高、代谢异常与CRP升高共存、代谢异常与sICAM-1升高共存、代谢异常与sE选择素升高共存、代谢异常与血管紧张素II升高共存的多因素调整比值比（95%置信区间）分别为2.209（范围1.594 - 3.062）、2.820（范围1.992 - 3.992）、2.370（范围1.665 - 3.374）、1.893（范围1.331 - 2.691）、2.545（范围1.793 - 3.612）、2.990（范围2.102 - 4.252）、2.551（范围1.775 - 3.667）、2.223（范围1.544 - 3.220）、3.135（范围2.
