Institute for Digestive Research and Digestive Disease Center, Soonchunhyang University College of Medicine, Seoul, Korea.
Korean J Intern Med. 2010 Dec;25(4):364-71. doi: 10.3904/kjim.2010.25.4.364. Epub 2010 Nov 27.
BACKGROUND/AIMS: To investigate the degree of cyclooxygenase-2 (COX-2) protein expression in chronic hepatitis and cirrhosis.
COX-2 protein expression was evaluated in 43 cases of chronic hepatitis and 24 cases of cirrhosis using immunohistochemical techniques. The COX-2 immunohistochemical staining score was assessed using the scoring systems of Pazirandeh et al and Qiu et al. and each scoring system was based on a sum of the parameters of staining intensity and distribution.
The mean COX-2 expression scores in chronic hepatitis and cirrhosis were 2.5 ± 1.3 vs. 3.3 ± 1.1 (p = 0.008), and 3.2 ± 2.0 vs. 4.5 ± 1.7 (p = 0.006), respectively, based on the Pazirandeh et al. and Qiu et al. scoring systems. The percentage samples of high COX-2 expression score (4 to 5) in chronic hepatitis and cirrhosis were 16.3% vs. 45.8% (p = 0.022), and 23.3% vs. 50% (p = 0.021), respectively, based on the two scoring systems. The mean COX-2 expression scores based on the severity of hepatic fibrosis scored using Ishak's modified staging system (fibrosis score 0 to 3 vs. 4 to 6) were 2.4 ± 1.3 vs. 3.2 ± 1.1 (p = 0.009), and 3.1 ± 2.0 vs. 4.3 ± 1.8 (p = 0.009), respectively, based on the two scoring systems.
COX-2 expression was significantly higher in liver cirrhosis group than in chronic hepatitis. COX-2 expression scores according to Ishak's staging was significantly higher in the advanced fibrosis group. COX-2 may play a role in the progression of hepatic fibrosis.
背景/目的：研究环氧化酶-2（COX-2）蛋白在慢性肝炎和肝硬化中的表达程度。
采用免疫组织化学技术检测 43 例慢性肝炎和 24 例肝硬化患者的 COX-2 蛋白表达。COX-2 免疫组化染色评分采用 Pazirandeh 等和 Qiu 等的评分系统进行评估，每个评分系统均基于染色强度和分布参数的总和。
根据 Pazirandeh 等和 Qiu 等的评分系统，慢性肝炎和肝硬化的 COX-2 表达评分均值分别为 2.5±1.3 比 3.3±1.1（p=0.008）和 3.2±2.0 比 4.5±1.7（p=0.006）。慢性肝炎和肝硬化中高 COX-2 表达评分（4 至 5）的样本百分比分别为 16.3%比 45.8%（p=0.022）和 23.3%比 50%（p=0.021）。根据 Ishak 改良分期系统（纤维化评分 0 至 3 比 4 至 6）评估的肝纤维化严重程度的 COX-2 表达评分均值分别为 2.4±1.3 比 3.2±1.1（p=0.009）和 3.1±2.0 比 4.3±1.8（p=0.009）。
COX-2 在肝硬化组中的表达明显高于慢性肝炎组。根据 Ishak 分期，COX-2 在晚期纤维化组中的表达评分显著更高。COX-2 可能在肝纤维化的进展中发挥作用。
