Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
Korean J Intern Med. 2010 Dec;25(4):450-3. doi: 10.3904/kjim.2010.25.4.450. Epub 2010 Nov 27.
A 63-year-old female was admitted to our hospital with a tender abdominal wall mass about 15 cm in diameter, which she had for 1 month. About 1 week earlier, the patient had also perceived a mass in the neck area. Computed tomography revealed huge thyroid and periumbilical masses. The thyroid hormone levels were consistent with a hyperthyroid state. Pathological examination of the thyroid mass was compatible with anaplastic thyroid carcinoma (ATC) and the abdominal cutaneous mass was shown to be metastatic ATC. Despite palliative radiotherapy and chemotherapy, the patient died of respiratory failure on her 63rd day of hospitalization. This case demonstrates that abdominal cutaneous metastasis and hyperthyroidism can occur as initial manifestations of ATC. To our knowledge, this is the first reported case.
一位 63 岁女性因直径约 15 厘米的腹壁触痛性肿块而入院，该肿块已存在 1 个月。大约 1 周前，患者还感觉到颈部有肿块。计算机断层扫描显示巨大的甲状腺和脐周肿块。甲状腺激素水平符合甲状腺功能亢进状态。甲状腺肿块的病理检查符合间变性甲状腺癌（ATC），腹部皮肤肿块为转移性 ATC。尽管进行了姑息性放疗和化疗，患者还是在住院的第 63 天因呼吸衰竭而死亡。本例表明，腹部皮肤转移和甲状腺功能亢进症可作为 ATC 的首发表现。据我们所知，这是首例报道。
