Neurological Clinic Research Unit, Institute of Molecular Medicine, Lisbon School of Medicine, Lisbon, Portugal.
Ther Adv Neurol Disord. 2010 Mar;3(2):117-26. doi: 10.1177/1756285609352366.
Parkinson's disease is a common neurodegenerative disorder with the particular feature of having various available treatments with proven efficacy. However, no treatment is curative. Recent trial results provided data for the discussion about the potential disease-modifying effect of new drugs as well as of other therapeutic strategies. The changing clinical phenotype following the progression of the disease multiplies the number of treatment targets and makes the application of recommendations from guidelines or other treatment algorithms to the individual patient a complex task. In the present manuscript, we discuss the treatment management of three case studies illustrating different stages of disease with distinct phenomenology. The proposed therapeutic alternatives are discussed based on the best data available; that is, treatment guidelines, clinical trial results or observational data.
帕金森病是一种常见的神经退行性疾病，其特点是有多种已被证实有效的治疗方法。然而，没有一种治疗方法是治愈性的。最近的临床试验结果为讨论新药的潜在疾病修饰作用以及其他治疗策略提供了数据。随着疾病的进展，临床表型的变化增加了治疗靶点的数量，使得将指南或其他治疗算法中的建议应用于个体患者成为一项复杂的任务。在本文中，我们讨论了三个病例研究的治疗管理，这些病例研究说明了不同阶段的疾病具有不同的表型。所提出的治疗选择是基于现有的最佳数据讨论的，即治疗指南、临床试验结果或观察性数据。
