高胆红素血症大鼠的听觉脑干反应：第一部分。

Auditory brainstem response in hyperbilirubinemic rat: Part I.

作者信息

Kuriyama M, Konishi Y, Sudo M

机构信息

Department of Pediatrics, Fukui Medical School, Japan.

出版信息

Biol Neonate. 1990;58(1):32-40. doi: 10.1159/000243228.

DOI:10.1159/000243228

PMID:2117972

Abstract

The effect of hyperbilirubinemia on the auditory brainstem response (ABR) of rats and its change by hyperosmolality were examined. The ABR wave I did not change significantly. In bilirubin-loaded rats, the latencies of wave II and IV were prolonged and the amplitudes decreased. Bilirubin injection damaged the central auditory pathway but the peripheral auditory pathway was spared. These ABR changes were reversible in the acute phase of hyperbilirubinemia. Mannitol administration hastened the appearance of the ABR peaks and the recovery of the changed ABR. This tendency was more remarkable in latency changes than in amplitude changes.

摘要

研究了高胆红素血症对大鼠听觉脑干反应（ABR）的影响及其因高渗状态而发生的变化。ABR波I无明显变化。在胆红素负荷的大鼠中，波II和波IV的潜伏期延长，波幅降低。胆红素注射损伤了中枢听觉通路，但外周听觉通路未受影响。这些ABR变化在高胆红素血症急性期是可逆的。给予甘露醇可加速ABR波峰的出现以及ABR变化的恢复。这种趋势在潜伏期变化方面比波幅变化更为显著。