[氯沙坦对大鼠动脉血压及外侧缰核和内侧缰核神经元单位放电的影响]
[Effect of losartan on arterial blood pressure and unit discharging of neurons in LHb and MHb of rat].
作者信息
Pan Yu-Zhen, Wang Xiao-Mei, Wu Shui-Sheng, Wang Shao
机构信息
Department of Physiology, The School of Basic Medical Sciences, Norman Bethune University of Medical Sciences, Jilin Changchun 130021, China.
出版信息
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2002 Feb;18(1):23-5.
AIM AND METHODS
To investigate the effect of 2 mg/kg and 10 mg/kg losartan intraperitoneally (i.p) on arterial blood pressure (AP) and heart rate (HR) in rat and the involvement in the activity of habenulas neurons. Glass micropipette was used to record any changes of unit discharging of neurons in LHb and MHb before and after losartan was intraperitoneally injected.
RESULTS
AP and HR were not significantly changed by 2 mg/kg losartan (i.p). However, AP was apparently decreased by 10 mg/kg losartan (i.p), but HR was unchanged. After 10 mg/kg losartan (i.p), 66.66% (12/18) unit discharging of neurons in LHb were increased in frequency, and 61.90% (13/21) in MHb were decreased.
CONCLUSION
AP of rat was significantly decreased by 10 mg/kg losartan (i.p). Depressor effect of losartan (i.p) was involved in the excision of neurons in LHb and the inhibition in MHb.
目的与方法
研究腹腔注射2毫克/千克和10毫克/千克氯沙坦对大鼠动脉血压（AP）和心率（HR）的影响以及对缰核神经元活动的参与情况。在腹腔注射氯沙坦前后，使用玻璃微电极记录外侧缰核（LHb）和内侧缰核（MHb）神经元单位放电的任何变化。
结果
腹腔注射2毫克/千克氯沙坦对动脉血压和心率无显著影响。然而，腹腔注射10毫克/千克氯沙坦可使动脉血压明显降低，但心率未变。腹腔注射10毫克/千克氯沙坦后，外侧缰核66.66%（12/18）的神经元单位放电频率增加，内侧缰核61.90%（13/21）的神经元单位放电频率降低。
结论
腹腔注射10毫克/千克氯沙坦可使大鼠动脉血压显著降低。氯沙坦的降压作用与外侧缰核神经元的兴奋和内侧缰核的抑制有关。
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