褪黑素对外侧缰核痛觉神经元放电频率的影响及可能机制
[Effect and possible mechanism of melatonin on the firing rate of pain neurons in lateral habenular nucleus].
作者信息
Lin Jlan-ping, Xia Ying-hong, Zhao Hua
机构信息
Department of Physiology, School of Basic Medical Sciences of Jilin University, Changchun 130021, China.
出版信息
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2006 Aug;22(3):322-5.
AIM
The effect and possible mechanism of Melatonin (MEL) on firing rate of pain neurons in lateral habenular nucleus of rats were investigated in the experiment.
METHODS
Single extracellular firing were recorded to study the firing rate changes of pain neurons and sensitivity changes to pain stimulation induced by MEL in LHb of rats. Reverse effect of naloxone on the analgesia induced by melatonin was also observed.
RESULTS
Melatonin showed the effects on the firing of pain neurons in the LHb and decreased the sensitivity of pain neurons to pain stimulation, which could be reversed by naloxone.
CONCLUSION
Melatonin can change the responses of pain neurons to pain stimulation via opioid receptor in the LHb, which might be one of analgesic mechanisms by MEL.
目的
本实验研究褪黑素（MEL）对大鼠外侧缰核痛觉神经元放电频率的影响及可能机制。
方法
采用细胞外单通道记录技术，观察MEL对大鼠外侧缰核痛觉神经元放电频率及对痛刺激敏感性的影响，并观察纳洛酮对褪黑素诱导的镇痛作用的反向影响。
结果
褪黑素可影响外侧缰核痛觉神经元的放电，降低痛觉神经元对痛刺激的敏感性，且该作用可被纳洛酮逆转。
结论
褪黑素可通过外侧缰核中的阿片受体改变痛觉神经元对痛刺激的反应，这可能是褪黑素的镇痛机制之一。
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