Cojocaru Inimioara Mihaela, Cojocaru M, Tănăsescu R, Iliescu Iuliana, Dumitrescu Laura, Silosi Isabela
Carol Davila University of Medicine and Pharmacy, Department of Neurology, Colentina Clinical Hospital, Bucharest.
Rom J Intern Med. 2009;47(4):393-6.
Cerebral ischemia initiates an inflammatory response in the brain and periphery. Inflammatory mechanisms, including IL-6, are suspected to play a role in arterial thrombogenesis. Their presence in the periphery is still controversial. The question arises as to whether IL-6 might directly contribute to cerebral infarct pathogenesis. IL-6 has several pro-inflammatory effects which may contribute to the induction and evolution of early inflammatory injury in the brain and its vasculature. The objective of this study was to test the hypothesis that there is a relationship between inflammation and the ischemic stroke measuring the levels of IL-6 in the blood of acute ischemic stroke patients. Plasma IL-6 was measured in 46 patients in the first 24 hours after acute ischemic stroke and in 98 controls matched for sex and age. Forty-five out of 46 acute ischemic stroke patients presented high IL-6 values. Fourteen out of 98 controls presented IL-6 values higher than normal. Mean level of circulating IL-6 was in acute ischemic stroke patients 26.5 +/- 2.3 pg/mL (range 6.4-161.3 pg/mL), significantly higher as compared to that in controls 3.9 +/- 1.5 pg/mL (range 2.3-5.9 pg/mL) [p < 0.0001, 95% CI (9.186 to 457.53)]. In our study, IL-6 levels were significantly elevated in the first 24 hours after ischemic stroke. This observation supports the hypothesis that IL-6 production is an inflammatory response to acute hypoxic-ischemic injury. IL-6 may serve as warning sign, because it increases early in inflammation.
脑缺血会引发大脑和外周的炎症反应。包括白细胞介素 - 6（IL - 6）在内的炎症机制被怀疑在动脉血栓形成中起作用。其在外周的存在仍存在争议。问题在于IL - 6是否可能直接促成脑梗死的发病机制。IL - 6具有多种促炎作用，可能有助于大脑及其血管早期炎症损伤的诱导和演变。本研究的目的是通过检测急性缺血性中风患者血液中IL - 6的水平来验证炎症与缺血性中风之间存在关联这一假设。在46例急性缺血性中风患者急性发作后的头24小时内以及98例年龄和性别匹配的对照组中测量血浆IL - 6。46例急性缺血性中风患者中有45例IL - 6值较高。98例对照组中有14例IL - 6值高于正常水平。急性缺血性中风患者循环IL - 6的平均水平为26.5±2.3 pg/mL（范围6.4 - 161.3 pg/mL），与对照组的3.9±1.5 pg/mL（范围2.3 - 5.9 pg/mL）相比显著更高[p < 0.0001，95%可信区间（9.186至457.53）]。在我们的研究中，缺血性中风后的头24小时内IL - 6水平显著升高。这一观察结果支持了IL - 6的产生是对急性缺氧缺血性损伤的炎症反应这一假设。IL - 6可能作为一个警示信号，因为它在炎症早期就会升高。
