肺小细胞癌：基础水平及经五肽胃泌素刺激后的血清降钙素和血清组胺酶（二胺氧化酶）

Small cell carcinoma of the lung: serum calcitonin and serum histaminase (diamine oxidase) at basal levels and stimulated by pentagastrin.

作者信息

Hansen M, Hansen H H, Tryding N

出版信息

Acta Med Scand. 1978;204(4):257-61. doi: 10.1111/j.0954-6820.1978.tb08436.x.

DOI:10.1111/j.0954-6820.1978.tb08436.x

Abstract

Investigations were performed to evaluate the incidence of increased serum calcitonin and histaminase in 79 patients with untreated small cell carcinoma of the lung (SSC). In addition, serum calcitonin was measured following pentagastrin stimulation in 19 of these patients. Serum calcitonin was elevated in 54 of 79 patients (68%), 20 patients (25%) having a level usually associated with the diagnosis of medullary carcinoma of the thyroid (MCT). The levels of histaminase, on the other hand, did not differ from the distribution in normals. In three of 19 patients undergoing the pentagastrin stimulation test, calcitonin was significantly increased. Thus, serum calcitonin is frequently elevated in patients with SCC and a positive pentagastrin test is not pathognomonic of MCT.

摘要

对79例未经治疗的肺小细胞癌（SSC）患者进行了调查，以评估血清降钙素和组胺酶升高的发生率。此外，对其中19例患者进行了五肽胃泌素刺激后血清降钙素的检测。79例患者中有54例（68%）血清降钙素升高，20例（25%）的水平通常与甲状腺髓样癌（MCT）的诊断相关。另一方面，组胺酶水平与正常分布无差异。在接受五肽胃泌素刺激试验的19例患者中，有3例降钙素显著升高。因此，SSC患者血清降钙素常升高，五肽胃泌素试验阳性并非MCT的特征性表现。