Baylin S B, Abeloff M D, Wieman K C, Tomford J W, Ettinger D S
N Engl J Med. 1975 Dec 18;293(25):1286-90. doi: 10.1056/NEJM197512182932504.
To investigate the possible embryologic relation between small-cell carcinoma of the lung and medullary thyroid carcinoma, we measured plasma histaminase (an enzyme found in medullary carcinoma tissue) in 25 patients with small-cell tumors. The assays used histamine and putrescine as substrates. Thirty-two per cent of the patients by the histamine assay, and 31 per cent by the putrescine, had values greater than +2 S.D. from the mean for 63 normal persons. In contrast, among 20 patients with squamous and large-cell lung tumors, one (by the histamine assay), and two (by the putrescine) had elevated values. In four of five autopsy cases, histaminase was high in small-cell carcinoma tissue. The enzyme in plasma and in tumor behaved as classic histaminase in substrate specificity, and in response to inhibitors. The data support the proposed embryologic relation between small-cell lung carcinoma and medullary thyroid carcinoma, and further associate histaminase with some neural crest tumors.
为了研究肺小细胞癌与甲状腺髓样癌之间可能存在的胚胎学关系，我们检测了25例小细胞肿瘤患者血浆中的组胺酶（一种在髓样癌组织中发现的酶）。检测使用组胺和腐胺作为底物。通过组胺检测，32%的患者以及通过腐胺检测，31%的患者的值高于63名正常人平均值的+2个标准差。相比之下，在20例鳞状和大细胞肺癌患者中，1例（通过组胺检测）和2例（通过腐胺检测）的值升高。在5例尸检病例中，有4例小细胞癌组织中的组胺酶含量较高。血浆和肿瘤中的这种酶在底物特异性和对抑制剂的反应方面表现为典型的组胺酶。这些数据支持了肺小细胞癌与甲状腺髓样癌之间所提出的胚胎学关系，并进一步将组胺酶与一些神经嵴肿瘤联系起来。
