Zhou X P, Zhao M Y, Ji Y Z, Guo Z N, Kong L S
Department of Neurosurgery, Changhai Hospital, Second Military Medical College, Shanghai.
Chin Med J (Engl). 1990 Apr;103(4):335-8.
The dynamic changes of thyroid hormone levels in patients with severe head injury were observed. The results showed that the serum thyroid hormone levels changed rapidly within several hours after the injury and the mean levels of serum total T3 and T4 (TT3, TT4) decreased while high reverse triiodothyronine (rT3) increased significantly. Serum TT3, TT4 and rT3 levels returned to normal gradually in 2 to 3 weeks after the injury in the surviving group, whereas serum total T4 gradually declined and rT3 steadily increased in the fatal group. The mean levels of serum TSH remained unchanged in both groups. Therefore, the use of the levels of serum thyroid hormones as adjuvant indices can be helpful in making pertinent judgements of the severity and prognosis of severe head injuries.
观察了重型颅脑损伤患者甲状腺激素水平的动态变化。结果显示，损伤后数小时内血清甲状腺激素水平迅速变化，血清总T3和T4（TT3、TT4）平均水平下降，而高反三碘甲状腺原氨酸（rT3）显著升高。存活组损伤后2至3周血清TT3、TT4和rT3水平逐渐恢复正常，而死亡组血清总T4逐渐下降，rT3持续升高。两组血清促甲状腺激素平均水平均无变化。因此，将血清甲状腺激素水平作为辅助指标有助于对重型颅脑损伤的严重程度和预后做出相关判断。
