Osotimehin B, Awotedu A A
Trop Geogr Med. 1981 Sep;33(3):281-6.
A study of the serum concentrations of the thyroid hormones thyroxine (T4), triiodothyronine (T3) and reverse triiodothyronine (rT3), thyrotropin (TSH) and the thyroid hormone binding proteins (thyroxine binding globulin (TBG), and thyroxine binding pre-albumin (TBPA)) in non-hospitalized adult Nigerian African subjects was conducted. The subjects were divided into three subgroups, male subjects, non-pregnant female subjects and pregnant female subjects to highlight peculiarities of each sub-group. All three subgroups showed elevation of TBG concentration as compared to British subjects. A statistically significant difference was observed in the concentrations of T4, T3, and TBG in the pregnant female subjects compared to the male and the non-pregnant subjects. A statistically significant difference was also observed between the concentrations rT3 in the male and pregnant female subjects compared to the non-pregnant female subjects. No statistically significant difference was observed between the concentrations of TSH, and TBPA, in all three subgroups, although the mean values for TSH were highest in the pregnant female subjects and the mean values for TBPA and albumin were lowest in this same group. The significance of these findings are discussed in relation to the evaluation of thyroid function in the adult African subject.
对未住院的成年尼日利亚非洲受试者的血清甲状腺激素浓度进行了研究，这些激素包括甲状腺素（T4）、三碘甲状腺原氨酸（T3）和反三碘甲状腺原氨酸（rT3）、促甲状腺激素（TSH）以及甲状腺激素结合蛋白（甲状腺素结合球蛋白（TBG）和甲状腺素结合前白蛋白（TBPA））。受试者被分为三个亚组，即男性受试者、未怀孕女性受试者和怀孕女性受试者，以突出每个亚组的特点。与英国受试者相比，所有三个亚组的TBG浓度均升高。与男性和未怀孕受试者相比，怀孕女性受试者的T4、T3和TBG浓度存在统计学显著差异。与未怀孕女性受试者相比，男性和怀孕女性受试者的rT3浓度之间也存在统计学显著差异。尽管TSH的平均值在怀孕女性受试者中最高，而TBPA和白蛋白的平均值在同一组中最低，但在所有三个亚组中，TSH和TBPA的浓度之间未观察到统计学显著差异。结合对成年非洲受试者甲状腺功能的评估，讨论了这些发现的意义。
